Effect of plasma treatment on the release kinetics of a chemotherapy drug from biodegradable polyester films and polyester urethane films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F18%3A63521362" target="_blank" >RIV/70883521:28110/18:63521362 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/18:63521362

Výsledek na webu

<a href="http://dx.doi.org/10.1080/00914037.2017.1309543" target="_blank" >http://dx.doi.org/10.1080/00914037.2017.1309543</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00914037.2017.1309543" target="_blank" >10.1080/00914037.2017.1309543</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of plasma treatment on the release kinetics of a chemotherapy drug from biodegradable polyester films and polyester urethane films

Popis výsledku v původním jazyce

Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and polyester urethane. The authors utilized two systems to achieve this, the first being diffuse coplanar surface barrier discharge, applying air as the gaseous medium, while the other involved capacitively coupled radio frequency discharge plasma under an argon atmosphere with hexamethyldisiloxane. Results showed that both forms of plasma treatment positively reduced the undesirable burst effect and benefited the release rate of TMZ. The hydrolytic degradability of the materials was slightly enhanced following hydrophilization, whereas the same diminished after hydrophobization had taken place. This was especially true for PLA due to modification of its wettability.

Název v anglickém jazyce

Effect of plasma treatment on the release kinetics of a chemotherapy drug from biodegradable polyester films and polyester urethane films

Popis výsledku anglicky

Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and polyester urethane. The authors utilized two systems to achieve this, the first being diffuse coplanar surface barrier discharge, applying air as the gaseous medium, while the other involved capacitively coupled radio frequency discharge plasma under an argon atmosphere with hexamethyldisiloxane. Results showed that both forms of plasma treatment positively reduced the undesirable burst effect and benefited the release rate of TMZ. The hydrolytic degradability of the materials was slightly enhanced following hydrophilization, whereas the same diminished after hydrophobization had taken place. This was especially true for PLA due to modification of its wettability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Polymeric Materials

ISSN

0091-4037

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

161-173

Kód UT WoS článku

000428134500004

EID výsledku v databázi Scopus

2-s2.0-85029676535