Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F21%3A63536858" target="_blank" >RIV/70883521:28110/21:63536858 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28610/21:63536858 RIV/00216208:11320/21:10436040 RIV/68407700:21220/21:00351325

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0257897221005764" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0257897221005764</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.surfcoat.2021.127402" target="_blank" >10.1016/j.surfcoat.2021.127402</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release

Popis výsledku v původním jazyce

Drug-loaded polymers are desirable for the controlled administration of bioactive molecules to biological media because polymer viscoelasticity can be translated into benefits of tissue-contacting materials. Here, we report on plasma-assisted deposition of polyester thin films performed via thermal evaporation of polylactic acid (PLA). The films can be produced with the chemical composition and polymer topology precisely tuned by the discharge power. At low power, weakly cross-linked films are produced with the chemical motif resembling that of PLA, the molar mass distribution peaking at ~350 g × mol−1 and skewing to larger species. At high power, highly cross-linked films are produced with a worse resemblance to PLA. The films swell and dissolve in water, releasing oligomers with the dissolution kinetics spanning over a broad time scale of 10−1–104 s. The released oligomers undergo hydrolysis at the time scale of days and with the final product of lactic acid, meeting the biocompatibility demands. When dissolving, the films expose micrometre-sized pores or buckling instabilities, depending on the discharge power. The phenomenon can be used for controlled release of nisin, an antibacterial peptide so that an hour-delayed release is achieved via the pore-mediated diffusion, whereas a minute-delayed release is achieved through the buckling. Nisin-loaded polyester plasma polymer films are effective against Micrococcus luteus, the bactericidal activity correlating with the drug release kinetics. Hence, the film design holds promise for developing advanced wound dressing materials and other tissue-contacting devices with tunable therapeutic effect.

Název v anglickém jazyce

Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release

Popis výsledku anglicky

Drug-loaded polymers are desirable for the controlled administration of bioactive molecules to biological media because polymer viscoelasticity can be translated into benefits of tissue-contacting materials. Here, we report on plasma-assisted deposition of polyester thin films performed via thermal evaporation of polylactic acid (PLA). The films can be produced with the chemical composition and polymer topology precisely tuned by the discharge power. At low power, weakly cross-linked films are produced with the chemical motif resembling that of PLA, the molar mass distribution peaking at ~350 g × mol−1 and skewing to larger species. At high power, highly cross-linked films are produced with a worse resemblance to PLA. The films swell and dissolve in water, releasing oligomers with the dissolution kinetics spanning over a broad time scale of 10−1–104 s. The released oligomers undergo hydrolysis at the time scale of days and with the final product of lactic acid, meeting the biocompatibility demands. When dissolving, the films expose micrometre-sized pores or buckling instabilities, depending on the discharge power. The phenomenon can be used for controlled release of nisin, an antibacterial peptide so that an hour-delayed release is achieved via the pore-mediated diffusion, whereas a minute-delayed release is achieved through the buckling. Nisin-loaded polyester plasma polymer films are effective against Micrococcus luteus, the bactericidal activity correlating with the drug release kinetics. Hence, the film design holds promise for developing advanced wound dressing materials and other tissue-contacting devices with tunable therapeutic effect.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Surface &amp; Coatings Technology

ISSN

0257-8972

e-ISSN

—

Svazek periodika

421

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000666583900038

EID výsledku v databázi Scopus

2-s2.0-85108403120