Core–shell PLA–PVA porous microparticles as carriers for bacteriocin nisin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F17%3A63516637" target="_blank" >RIV/70883521:28610/17:63516637 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1080/02652048.2017.1324919" target="_blank" >http://dx.doi.org/10.1080/02652048.2017.1324919</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/02652048.2017.1324919" target="_blank" >10.1080/02652048.2017.1324919</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Core–shell PLA–PVA porous microparticles as carriers for bacteriocin nisin

Popis výsledku v původním jazyce

This work is focused on preparation of novel porous type of core–shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent–nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy. Encapsulation efficiency and release profile of nisin from the microparticles were studied by high performance liquid chromatography. Antibacterial activity of the prepared systems was tested by dilution and spread plate technique. Results showed the microparticles in the size range of 9–16 μm in diameter with spherical multi-hollow core–shell structure. The presence of cross-linking agent GA influences the release profile of the peptide and has synergistic effect on Listeria monocytogenes growth reduction.

Název v anglickém jazyce

Core–shell PLA–PVA porous microparticles as carriers for bacteriocin nisin

Popis výsledku anglicky

This work is focused on preparation of novel porous type of core–shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent–nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy. Encapsulation efficiency and release profile of nisin from the microparticles were studied by high performance liquid chromatography. Antibacterial activity of the prepared systems was tested by dilution and spread plate technique. Results showed the microparticles in the size range of 9–16 μm in diameter with spherical multi-hollow core–shell structure. The presence of cross-linking agent GA influences the release profile of the peptide and has synergistic effect on Listeria monocytogenes growth reduction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Microencapsulation

ISSN

0265-2048

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

243-249

Kód UT WoS článku

000405503100002

EID výsledku v databázi Scopus

2-s2.0-85021127119