Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F18%3A63521424" target="_blank" >RIV/70883521:28610/18:63521424 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S1773224718302910" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224718302910</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jddst.2018.06.020" target="_blank" >10.1016/j.jddst.2018.06.020</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents
Popis výsledku v původním jazyce
A major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120 nm, a ζ-potential between 30 and 35 mV with good stability in human serum, and low hemolytic activity of up to 100 μg/mL. Over 800 μg of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule.
Název v anglickém jazyce
Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents
Popis výsledku anglicky
A major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120 nm, a ζ-potential between 30 and 35 mV with good stability in human serum, and low hemolytic activity of up to 100 μg/mL. Over 800 μg of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30404 - Biomaterials (as related to medical implants, devices, sensors)
Návaznosti výsledku
Projekt
<a href="/cs/project/LO1504" target="_blank" >LO1504: Centrum polymerních systémů plus</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Drug Delivery Science and Technology
ISSN
1773-2247
e-ISSN
—
Svazek periodika
47
Číslo periodika v rámci svazku
Neuveden
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
10
Strana od-do
67-76
Kód UT WoS článku
000445162500009
EID výsledku v databázi Scopus
2-s2.0-85049463356