Influence of the structure of regioselectively oxidized polysaccharides on the anticancer-drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63560498" target="_blank" >RIV/70883521:28610/22:63560498 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of the structure of regioselectively oxidized polysaccharides on the anticancer-drug delivery

Popis výsledku v původním jazyce

Polysaccharides have been investigated as potential anticancer-drug carriers due to their natural origin, biocompatibility and large potential for modifications. They are however notoriously known for their structural diversity and lack of suitable functional groups, which complicate their drug delivery capability. Regioselective oxidation of polysaccharides to corresponding dicarboxy polysaccharides (DCPs) provides a unique opportunity to remedy this issue. Sequential periodate/chlorite oxidation introduces two -COOH groups per each oxidized unit, which are capable to conjugate platinum(Il) complexes, while preserving the main structural features of source polysaccharides intact. Hence, we performed selective two-stage oxidation of four structurally different polysaccharides (cellulose, dextrin, dextran and hyaluronate), loaded them with the equivalent amount of cisplatin (CP), and compared their properties as drug carriers. The oxidized cellulose (DCC) was found to be the most cytotoxic of all compounds tested, including free CP. The oxidized hyaluronate (DCH) showed the highest accumulation in cancer cells, which was correlated to the expression of CD44 receptors. Both derivatives are thus excellent candidates for further research.

Název v anglickém jazyce

Influence of the structure of regioselectively oxidized polysaccharides on the anticancer-drug delivery

Popis výsledku anglicky

Polysaccharides have been investigated as potential anticancer-drug carriers due to their natural origin, biocompatibility and large potential for modifications. They are however notoriously known for their structural diversity and lack of suitable functional groups, which complicate their drug delivery capability. Regioselective oxidation of polysaccharides to corresponding dicarboxy polysaccharides (DCPs) provides a unique opportunity to remedy this issue. Sequential periodate/chlorite oxidation introduces two -COOH groups per each oxidized unit, which are capable to conjugate platinum(Il) complexes, while preserving the main structural features of source polysaccharides intact. Hence, we performed selective two-stage oxidation of four structurally different polysaccharides (cellulose, dextrin, dextran and hyaluronate), loaded them with the equivalent amount of cisplatin (CP), and compared their properties as drug carriers. The oxidized cellulose (DCC) was found to be the most cytotoxic of all compounds tested, including free CP. The oxidized hyaluronate (DCH) showed the highest accumulation in cancer cells, which was correlated to the expression of CD44 receptors. Both derivatives are thus excellent candidates for further research.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/EF16_028%2F0006243" target="_blank" >EF16_028/0006243: Rozvoj kapacit pro výzkum a vývoj UTB ve Zlíně</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů