Self-assembled Oxidized Dextran Nanogels for Cisplatin Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574938" target="_blank" >RIV/70883521:28610/23:63574938 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Self-assembled Oxidized Dextran Nanogels for Cisplatin Delivery

Popis výsledku v původním jazyce

Cisplatin (CP, cis-[Pt(NH3)2Cl2]) is a first-line chemotherapeutic used for patients diagnosed with various types of cancer. However, its use is accompanied by neuro-, nephro- and ototoxicity as a result of its nonspecific action. The CP conjugation to polysaccharides advantageously reduce off-toxicity, protect the conjugated CP and improve accumulation in tumor (enhanced permeability and retention effect). Dextrans are a-(1 ➔6) glucans with a-(1 ➔3) branching and are used as plasma vol ume expanders, antithrombotic agents etc. Dicarboxylated dextran (DXA) prepared via sequential periodate-chlorite oxidation was conjugated with CP and showed highest overall cellular uptake and high toxicity towards malignant cell lines among the other dicaboxylated polysaccharide-CP conjugates. Furthermore, the migrastatic and anticancer efficacy was found to be dependent on the formation of CP-DXA nano-assembliesY1 Thus, the DXA macromolecules containing high -COOH group density were crosslinked via CP bidentate binding to form CP-DXA nanogels and their physico-chemical and biological properties evaluated.

Název v anglickém jazyce

Self-assembled Oxidized Dextran Nanogels for Cisplatin Delivery

Popis výsledku anglicky

Cisplatin (CP, cis-[Pt(NH3)2Cl2]) is a first-line chemotherapeutic used for patients diagnosed with various types of cancer. However, its use is accompanied by neuro-, nephro- and ototoxicity as a result of its nonspecific action. The CP conjugation to polysaccharides advantageously reduce off-toxicity, protect the conjugated CP and improve accumulation in tumor (enhanced permeability and retention effect). Dextrans are a-(1 ➔6) glucans with a-(1 ➔3) branching and are used as plasma vol ume expanders, antithrombotic agents etc. Dicarboxylated dextran (DXA) prepared via sequential periodate-chlorite oxidation was conjugated with CP and showed highest overall cellular uptake and high toxicity towards malignant cell lines among the other dicaboxylated polysaccharide-CP conjugates. Furthermore, the migrastatic and anticancer efficacy was found to be dependent on the formation of CP-DXA nano-assembliesY1 Thus, the DXA macromolecules containing high -COOH group density were crosslinked via CP bidentate binding to form CP-DXA nanogels and their physico-chemical and biological properties evaluated.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů