Advanced Engineering of Hyaluronan Coatings through Controlled Phase Separation and Inversion

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63577619" target="_blank" >RIV/70883521:28610/24:63577619 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28110/24:63577619

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Advanced Engineering of Hyaluronan Coatings through Controlled Phase Separation and Inversion

Popis výsledku v původním jazyce

This work explores application of phase separation phenomena for structuring of films made from hyaluronan (HU). HU is known for its biocompatibility and finds broad applicability in biomedical, tissue engineering and pharmaceutical research as well as practical use in cosmetics and dermatology.[1] A time-sequenced dispensing of different solution mixtures was applied under rotation on hyaluronan covered substrates to generate surface textures without the need for sacrificial removable templates or additives. Texturization of hyaluronic acid films was achieved through the application of two methods: phase separation and phase inversion. In the phase separation process, a mixture of good and poor solvents was applied to the surface,[2,3] resulting in the formation of surface relief on the scale of micrometers to submicrometers. Conversely, in the phase inversion approach, a solvent mixture, along with hyaluronic acid, was applied to a rotating surface, generating surface topography with features on the scale of submillimeters. Both methods are closely dependent on both the process parameters of the procedure and the molecular weight of the hyaluronic acid used. Thin hyaluronan films modified by phase separation exhibit improved mechanical properties. Together with the created surface relief featuring a higher specific surface area, this could represent an effective carrier for drug delivery.

Název v anglickém jazyce

Advanced Engineering of Hyaluronan Coatings through Controlled Phase Separation and Inversion

Popis výsledku anglicky

This work explores application of phase separation phenomena for structuring of films made from hyaluronan (HU). HU is known for its biocompatibility and finds broad applicability in biomedical, tissue engineering and pharmaceutical research as well as practical use in cosmetics and dermatology.[1] A time-sequenced dispensing of different solution mixtures was applied under rotation on hyaluronan covered substrates to generate surface textures without the need for sacrificial removable templates or additives. Texturization of hyaluronic acid films was achieved through the application of two methods: phase separation and phase inversion. In the phase separation process, a mixture of good and poor solvents was applied to the surface,[2,3] resulting in the formation of surface relief on the scale of micrometers to submicrometers. Conversely, in the phase inversion approach, a solvent mixture, along with hyaluronic acid, was applied to a rotating surface, generating surface topography with features on the scale of submillimeters. Both methods are closely dependent on both the process parameters of the procedure and the molecular weight of the hyaluronic acid used. Thin hyaluronan films modified by phase separation exhibit improved mechanical properties. Together with the created surface relief featuring a higher specific surface area, this could represent an effective carrier for drug delivery.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20506 - Coating and films

Projekt

<a href="/cs/project/GA22-33307S" target="_blank" >GA22-33307S: Vývoj nových 3D hierarchicky strukturovaných polysacharidových a proteinových porézních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů