Imunologické biomarkery ve vztahu k expozici prašným částicím: průřezová studie v 17 městech střední Evropy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F71009396%3A_____%2F00%3A%230000032" target="_blank" >RIV/71009396:_____/00:#0000032 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immune biomarkers in relation to exposure to particulate matter : a cross-sectional survey in 17 cities of Central Europe

Popis výsledku v původním jazyce

A survey was conducted within the framework of the CESAR study to measure a panel of immune biomarkers in children from 6 CEE countries. Blood was collected from 366 school children aged 9 to 11 yr in 1996. Associations between PM10 and PM2.5 and each log-transformed biomarker concentration were studied by linear regression, in a two-stage model. The yearly average concentrations varied from 41 to 96 ?g/m3 for PM10 across the 17 study areas, from 29 to 67 ?g/m3 for PM2.5, and from 12 to 38 ?g/m3 for PM10-2.5 (coarse). Number of B, CD4 + , CD8 + , and NK lymphocytes increased with increasing concentration of PM, having adjusted for age, gender, parental smoking, laboratory of analysis, and recent respiratory illness. Differences in lymphocyte number were larger and statistically significant for exposure to PM2.5. Total IgG was increased with increasing concentration of PM, significantly in the case of PM2.5. The effect of coarse PM on lymphocyte numbers appears small in comparison to PM

Název v anglickém jazyce

Immune biomarkers in relation to exposure to particulate matter : a cross-sectional survey in 17 cities of Central Europe

Popis výsledku anglicky

A survey was conducted within the framework of the CESAR study to measure a panel of immune biomarkers in children from 6 CEE countries. Blood was collected from 366 school children aged 9 to 11 yr in 1996. Associations between PM10 and PM2.5 and each log-transformed biomarker concentration were studied by linear regression, in a two-stage model. The yearly average concentrations varied from 41 to 96 ?g/m3 for PM10 across the 17 study areas, from 29 to 67 ?g/m3 for PM2.5, and from 12 to 38 ?g/m3 for PM10-2.5 (coarse). Number of B, CD4 + , CD8 + , and NK lymphocytes increased with increasing concentration of PM, having adjusted for age, gender, parental smoking, laboratory of analysis, and recent respiratory illness. Differences in lymphocyte number were larger and statistically significant for exposure to PM2.5. Total IgG was increased with increasing concentration of PM, significantly in the case of PM2.5. The effect of coarse PM on lymphocyte numbers appears small in comparison to PM

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FQ - Veřejné zdravotnictví, sociální lékařství

OECD FORD obor

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Projekt

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Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inhalation Toxicology

ISSN

0895-8378

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

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EID výsledku v databázi Scopus

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