The importance of time: time delays in acute stroke

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F16%3A00011385" target="_blank" >RIV/75010330:_____/16:00011385 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/16:43911416

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0010865016300170" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0010865016300170</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2016.03.002" target="_blank" >10.1016/j.crvasa.2016.03.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The importance of time: time delays in acute stroke

Popis výsledku v původním jazyce

Endovascular treatment (EVT) of severe acute ischemic stroke (AIS) determined by large vessel occlusion (LVO) is effective and safe. Debate still goes on especially about time importance and utilization of advanced penumbra imaging at the expense of losing valuable minutes. We did a meta-analysis focused on time of randomized clinical trials (RCTs) that started to use methodically the new-tech stent retrievers. The chosen time interval was onset-groin time (from last seen well to sheath insertion in the cathlab). Primary outcome was good functional outcome (mRS of 0-2) at 90 days, secondary outcomes were mortality at 90 days and symptomatic intra-cerebral hemorrhage (sICH). Furthermore, we did a sub-analysis of the EVT patients to find a correlation between faster times and outcomes. We did the same sub-analysis including also single-arm registries that used modern stent retrievers. Totally data from 1287 patients (5 RCTs) were analyzed, whose 634 EVT patients were divided into two groups based on time (faster/slower than 240 min). emphasizing how delays could even worsen AIS. This meta-analysis supports the "Time is brain" strategy in treatment of acute ischemic stroke. In general, fast endovascular treatment (groin puncture within < 4 h) signifi cantly improves patients' outcomes. Healthcare systems should develop maximal effort to shorten pre-hospital and in-hospital delays in acute stroke patients. The earlier the patient is presenting, the more important is the fast track, offering chance for full neurologic recovery.

Název v anglickém jazyce

The importance of time: time delays in acute stroke

Popis výsledku anglicky

Endovascular treatment (EVT) of severe acute ischemic stroke (AIS) determined by large vessel occlusion (LVO) is effective and safe. Debate still goes on especially about time importance and utilization of advanced penumbra imaging at the expense of losing valuable minutes. We did a meta-analysis focused on time of randomized clinical trials (RCTs) that started to use methodically the new-tech stent retrievers. The chosen time interval was onset-groin time (from last seen well to sheath insertion in the cathlab). Primary outcome was good functional outcome (mRS of 0-2) at 90 days, secondary outcomes were mortality at 90 days and symptomatic intra-cerebral hemorrhage (sICH). Furthermore, we did a sub-analysis of the EVT patients to find a correlation between faster times and outcomes. We did the same sub-analysis including also single-arm registries that used modern stent retrievers. Totally data from 1287 patients (5 RCTs) were analyzed, whose 634 EVT patients were divided into two groups based on time (faster/slower than 240 min). emphasizing how delays could even worsen AIS. This meta-analysis supports the "Time is brain" strategy in treatment of acute ischemic stroke. In general, fast endovascular treatment (groin puncture within < 4 h) signifi cantly improves patients' outcomes. Healthcare systems should develop maximal effort to shorten pre-hospital and in-hospital delays in acute stroke patients. The earlier the patient is presenting, the more important is the fast track, offering chance for full neurologic recovery.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

234-240

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-84963853539