Mitochondrially targeted anti-cancer agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F10%3A00361635" target="_blank" >RIV/86652036:_____/10:00361635 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mito.2010.06.004" target="_blank" >http://dx.doi.org/10.1016/j.mito.2010.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mito.2010.06.004" target="_blank" >10.1016/j.mito.2010.06.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrially targeted anti-cancer agents

Popis výsledku v původním jazyce

Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification ofsuch structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance

Název v anglickém jazyce

Mitochondrially targeted anti-cancer agents

Popis výsledku anglicky

Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently,a considerable challenge.Mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans,have been a recent focus of research.Of these compounds, many are hydrophobic agents that associate with various subcellular organelles.Modification ofsuch structures with mitochondria-targeting moieties,for example tagging them with lipophilic cations,would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. We propose that mitochondrial targeting, in particular where the agent associates directly with the target,results in more specific and efficient anti-cancer drugs of potential high clinical relevance

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mitochondrion

ISSN

1567-7249

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

670-681

Kód UT WoS článku

000284660000011

EID výsledku v databázi Scopus

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