Adverse effect of tetracycline and doxycycline on reproductive tract development of CD1 mice

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adverse effect of tetracycline and doxycycline on reproductive tract development of CD1 mice

Popis výsledku v původním jazyce

Introduction: Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we testedthe effect of antibiotics on the reproductive parameters of male mice with the therapeutic dose used in humans. Methods: The outbred mouse strain CD1 with higher heterozygosity was exposed to three different doses for 14 days at puberty. Half of the therapeutic dose used in humans, the therapeutic dose, and double the therapeutic dose were used for the treatment. Adult males at the age of 70 days were used for the measurements. Results: We observed significant changes in most of the relevant reproductive parameters measured. There was a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of spe

Název v anglickém jazyce

Adverse effect of tetracycline and doxycycline on reproductive tract development of CD1 mice

Popis výsledku anglicky

Introduction: Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we testedthe effect of antibiotics on the reproductive parameters of male mice with the therapeutic dose used in humans. Methods: The outbred mouse strain CD1 with higher heterozygosity was exposed to three different doses for 14 days at puberty. Half of the therapeutic dose used in humans, the therapeutic dose, and double the therapeutic dose were used for the treatment. Adult males at the age of 70 days were used for the measurements. Results: We observed significant changes in most of the relevant reproductive parameters measured. There was a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of spe

Druh

O - Ostatní výsledky

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů