MicroRNA regulation of cancer metabolism: role in tumour suppression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00441822" target="_blank" >RIV/86652036:_____/14:00441822 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.004" target="_blank" >http://dx.doi.org/10.1016/j.mito.2014.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mito.2014.06.004" target="_blank" >10.1016/j.mito.2014.06.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNA regulation of cancer metabolism: role in tumour suppression

Popis výsledku v původním jazyce

Mitochondria are critical regulators of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders, including cancer. Altered metabolism is a common property of cancer cells that exhibit enhanced capacity to 'ferment' glucose to pyruvate and then lactate, even in the presence of sufficient oxygen to support mitochondrial metabolism. Recently, it was reported that microRNAs (miRNAs) regulate important signalling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Different regulatory mechanisms can control miRNA expression at the genetic or epigenetic level, thus affecting the biogenetic machinery via recruitment of specific transcription factors. Metabolic reprogramming that cancer cells undergo during tumorigenesis offers a wide range of potential targets to impair tumour progression. MiRNAs participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly r

Název v anglickém jazyce

MicroRNA regulation of cancer metabolism: role in tumour suppression

Popis výsledku anglicky

Mitochondria are critical regulators of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders, including cancer. Altered metabolism is a common property of cancer cells that exhibit enhanced capacity to 'ferment' glucose to pyruvate and then lactate, even in the presence of sufficient oxygen to support mitochondrial metabolism. Recently, it was reported that microRNAs (miRNAs) regulate important signalling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Different regulatory mechanisms can control miRNA expression at the genetic or epigenetic level, thus affecting the biogenetic machinery via recruitment of specific transcription factors. Metabolic reprogramming that cancer cells undergo during tumorigenesis offers a wide range of potential targets to impair tumour progression. MiRNAs participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly r

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mitochondrion

ISSN

1567-7249

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

part a SI

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

29-38

Kód UT WoS článku

000346624700005

EID výsledku v databázi Scopus

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