Mean value of LET for oncogenic effects of radon and its progeny

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652052%3A_____%2F19%3AN0000074" target="_blank" >RIV/86652052:_____/19:N0000074 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/rpd/article/186/2-3/159/5658465" target="_blank" >https://academic.oup.com/rpd/article/186/2-3/159/5658465</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncz194" target="_blank" >10.1093/rpd/ncz194</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mean value of LET for oncogenic effects of radon and its progeny

Popis výsledku v původním jazyce

The topic of the article is to define the average value of linear energy transfer (LET) for carcinogenic effects of radon progeny. The microdosimetric model of boundary specific energy is used. It follows that the effect at high LET should decrease approximately with the third power of LET. This is verified by the analysis of the relationship between radiation effects ratio and LET in published experiments with oncogenic transformation of mammalian cells irradiated with the monoenergetic alpha particles. If these cells are exposed with the radon irradiator, our analysis leads us to conclude that the oncogenic effect of radon progeny is comparable to that of alpha particles with a LET of 75 keV/μm. It is about a quarter lower than the LET value, where the effect of the monoenergetic alpha particles reaches its maximum level. Some implications for lung cancer due to radon inhalation may also be carefully examined.

Název v anglickém jazyce

Mean value of LET for oncogenic effects of radon and its progeny

Popis výsledku anglicky

The topic of the article is to define the average value of linear energy transfer (LET) for carcinogenic effects of radon progeny. The microdosimetric model of boundary specific energy is used. It follows that the effect at high LET should decrease approximately with the third power of LET. This is verified by the analysis of the relationship between radiation effects ratio and LET in published experiments with oncogenic transformation of mammalian cells irradiated with the monoenergetic alpha particles. If these cells are exposed with the radon irradiator, our analysis leads us to conclude that the oncogenic effect of radon progeny is comparable to that of alpha particles with a LET of 75 keV/μm. It is about a quarter lower than the LET value, where the effect of the monoenergetic alpha particles reaches its maximum level. Some implications for lung cancer due to radon inhalation may also be carefully examined.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

1742-3406

Svazek periodika

186

Číslo periodika v rámci svazku

2-3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

159-162

Kód UT WoS článku

000530582200003

EID výsledku v databázi Scopus

2-s2.0-85082779757