Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F12%3A00385635" target="_blank" >RIV/61389005:_____/12:00385635 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1093/rpd/ncs024" target="_blank" >http://dx.doi.org/10.1093/rpd/ncs024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncs024" target="_blank" >10.1093/rpd/ncs024</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

Popis výsledku v původním jazyce

Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival.

Název v anglickém jazyce

Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

Popis výsledku anglicky

Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BG - Jaderná, atomová a molekulová fyzika, urychlovače

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

—

Svazek periodika

151

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

570-579

Kód UT WoS článku

000308960900023

EID výsledku v databázi Scopus

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