Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F19%3A00501091" target="_blank" >RIV/86652079:_____/19:00501091 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081715:_____/19:00501091 RIV/61989592:15310/19:73596642 RIV/62157124:16370/19:43877852 RIV/86652079:_____/19:00551751

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/24/3/566" target="_blank" >https://www.mdpi.com/1420-3049/24/3/566</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24030566" target="_blank" >10.3390/molecules24030566</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones

Popis výsledku v původním jazyce

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application andngood patient compliance. (S)-8-Methyl-6,9-diazaspiro[4.5]decan-7,10-dione (alaptide), has been studied as a potential chemical permeation enhancer. Based on its structure, four selectednpiperazine-2,5-diones were synthesized by means of multi-step synthetic pathways. All the compounds were investigated on their ability to enhance the permeation of the model drugntheophylline from the hydrophilic medium propylene glycol:water (1:1). In vitro experiments were performed using vertical Franz diffusion cells at constant temperature 34 0.5 C and usingnfull-thickness pig (Sus scrofa f. domestica) ear skin. Withdrawn samples were analyzed by RP-HPLC for determination of the permeated amount of theophylline. All the compounds were applied in ration1:10 (w/w) relative to the amount of theophylline.

Název v anglickém jazyce

Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones

Popis výsledku anglicky

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application andngood patient compliance. (S)-8-Methyl-6,9-diazaspiro[4.5]decan-7,10-dione (alaptide), has been studied as a potential chemical permeation enhancer. Based on its structure, four selectednpiperazine-2,5-diones were synthesized by means of multi-step synthetic pathways. All the compounds were investigated on their ability to enhance the permeation of the model drugntheophylline from the hydrophilic medium propylene glycol:water (1:1). In vitro experiments were performed using vertical Franz diffusion cells at constant temperature 34 0.5 C and usingnfull-thickness pig (Sus scrofa f. domestica) ear skin. Withdrawn samples were analyzed by RP-HPLC for determination of the permeated amount of theophylline. All the compounds were applied in ration1:10 (w/w) relative to the amount of theophylline.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

566

Kód UT WoS článku

000458934000190

EID výsledku v databázi Scopus

2-s2.0-85061058020