Filtry
Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells
as a transmembrane cell-surface protein, but its ectodomain can be shed by ADAM17 to extracellular space. This study aims to elucidate the impact of CA IX shedding on cancer cells. METHODS: We generated a non-shed...
Oncology
- 2020 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy
and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface ADAM17. Here we investigated the CA IX ECD shedding in tumor cells undergoing progress due to an increased ECD shedding, ...
EB - Genetika a molekulární biologie
- 2016 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors
We examined the dependence of P2XRs activity on ectodomain structure and agonist potency. Using rat P2X2aR, P2X2bR, P2X3R, and chimeras having the ectodomain sequences of P2X3R instead of ectodomain sequences of P2X2aR and ...
ED - Fyziologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15
A disintegrin and metalloproteinase 10 (ADAM10) plays a major role in the ectodomain shedding of important surface molecules with physiological and pathological of ADAM10-mediated ectodomain shedding in vivo. reduc...
Biochemistry and molecular biology
- 2018 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
EMBRYOGLYCAN ECTODOMAINS REGULATE BIOLOGICAL ACTIVITY OF FGF-2 TO EMBRYONIC STEM CELLS
EB - Genetika a molekulární biologie
- 1998 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity
of ectodomains of inflammatory cytokines from the cell surface. We hypothesized that UDCA of bile duct ligation (BDL). UDCA decreases amount of shed TNF alpha, TGF alpha......
EB - Genetika a molekulární biologie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity
Several membrane-anchored signal mediators such as cytokines (e.g. TNF alpha) and growth factors are proteolytically shed from the cell surface by the metalloproteinase ADAM17, which, thus, has an essential role in inflammatory and developme...
Biochemistry and molecular biology
- 2023 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Embryoglycan ectodomains regulate biological activity of FGF-2 to embryonic stem cells.
Annotation not available...
EB - Genetika a molekulární biologie
- 1998 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Role of aromatic and charged ectodomain residues in the P2X4 receptor functions
The localization of ATP binding site(s) at P2X receptors and the molecular rearrangements associated with opening and closing of channels are still not well understood. We found that ectodomain residues lysines 67 and 313 and arginine 295 pl...
FH - Neurologie, neurochirurgie, neurovědy
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Tes...
ED - Fyziologie
- 2011 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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