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Výsledek výzkumu

Combined Therapy using Mesenchymal Stem Cells and Metal Nanoparticles: Perspectives for Ocular Injuries and Diseases

The study is based on large-scale patient-derived and literature-linked datasets.

Immunology

  • 2026
  • X
Výsledek výzkumu

Data supporting the article "ENHANCING ADIPOGENESIS IN WHARTON'S JELLY MULTIPOTENT MESENCHYMAL STROMAL CELLS: THE ROLE OF OLEIC AND LINOLEIC ACID SUPPLEMENTATION"

F 1. Adipogenic (AD) differentiation of WJ-MSCs and AT-MSCs (N=4 for each) following the std induction protocol.nF 2. Lipidomic profiles of WJ-MSCs and AT-MSCs (N=4) based on LC-MS. nF 3. Comparison of TG proportion in WJ-MSCs and AT-MSCs (N=4).nF 4....

Cell biology

  • 2026
  • X
Výsledek výzkumu

Dataset for article: Distinct regulation of early trafficking of the NMDA receptors by the ligand-binding domains of the GluN1 and GluN2A subunits

Raw data used for generating figures in the article. The study shows that different parts of the receptor—specifically the ligand-binding domains of the GluN1 and GluN2A subunits—play distinct roles in controlling how these receptors are processed an...

Neurosciences (including psychophysiology)

  • 2026
  • X
Výsledek výzkumu

Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study

Methods Scaffolds were fabricated from poly(ε-caprolactone) (PCL) using a controlled fiber-drawing technique to produce highly aligned microfibers with reproducible thickness and architecture. Their biocompatibility was examined in vitro using fibrob...

Surgery

  • 2026
  • Jimp
  • Odkaz
Výsledek výzkumu

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is ...

Neurosciences (including psychophysiology)

  • 2025
  • Jimp
  • Odkaz
Výsledek výzkumu

Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: implications for autologous therapy

Cases of hereditary retinal dystrophy (HRD) can be caused by mutations in the MERTK gene, which result in an autosomal recessive form of blindness (Retinitis Pigmentosa - RP) characterized by impaired phagocytosis of photoreceptor outer segments (POS...

Biomaterials (as related to medical implants, devices, sensors)

  • 2025
  • Jimp
  • Odkaz
Výsledek výzkumu

Delivery of Human iPSC-Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

In late stages of inherited and acquired retinal diseases such as Stargardt disease (STGD) or dry age-related macular degeneration (AMD), loss of retinal pigment epithelia (RPE) cells and subsequently photoreceptors in the macular area result in a dr...

Biomaterials (as related to medical implants, devices, sensors)

  • 2025
  • Jimp
  • Odkaz
Výsledek výzkumu

Validation of Lipophosphonoxin-loaded Polycaprolactone Nanofiber Dressing for Full-thickness Wounds in a Porcine Model

Background/Aim: This study investigated the therapeutic potential of lipophosphonoxin (LPPO), an antibacterial agent, loaded into polycaprolactone nanofiber dressings (NANO-LPPO) for full-thickness wound healing. Using a porcine model, we aimed to as...

Organic chemistry

  • 2025
  • Jimp
  • Odkaz
Výsledek výzkumu

Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Plasmonic titanium nitride (TiN) nanoparticles are emerging nanomaterials possessing several orders of magnitude higher absorption cross section, but also exhibit higher photostability compared to conventional photosenzitizers. In the recent years, T...

Toxicology

  • 2025
  • Jimp
  • Odkaz
Výsledek výzkumu

miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery

Ischemic stroke is a leading cause of mortality and long-term disability globally. One of its aspects is the breakdown of the blood-brain barrier (BBB). The disruption of BBB's integrity during stroke exacerbates neurological damage and hampers thera...

Neurosciences (including psychophysiology)

  • 2025
  • Jimp
  • Odkaz
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