Chybná regulace signálních drah v TNF-zprostředkované autoimunitě

Název projektu anglicky
Dysregulation of signaling pathways in TNF-mediated autoimmunity
Anotace anglicky
Tumor necrosis factor (TNF) is a potent pro-inflammatory cytokine involved in various autoimmune diseases. It can trigger transcriptional responses, but also induce highly inflammatory cell death. Among major regulators of TNF-induced cell death is the kinase TBK1. In vitro data indicated that TBK1 recruitment to TNF receptor is mediated by adaptors TANK and NAP1, although the role of these two proteins in vivo remains to be established. We prepared mice deficient in both TANK and NAP1. They are born in sub-Mendelian ratios, have defect in hair growth, develop dermatitis and multi-organ inflammation and die prematurely. This phenotype is largely rescued by TNF receptor 1 ablation. In addition, they have markedly increased proportion of activated B cells and CD8 T cells and, very surprisingly, also substantially elevated number of regulatory T cells. We will study how TANK and NAP1 mediated recruitment of TBK1 to pro-inflammatory complexes prevents autoimmunity and modulate adaptive immune system. This research will give important new information about immune homeostasis.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30102 - Immunology
OECD FORD - vedlejší obor
—
OECD FORD - další vedlejší obor
—
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EC - Imunologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
21. 5. 2024

Podobné projekty(10)