Role NK a NKT buněk v procesech negativní selekce v brzlíku

Název projektu anglicky
The function of NK and NKT cells in thymic negative selection
Anotace anglicky
Central tolerance, which operates in the thymus, is critical for the prevention of autoimmunity. This proces is largely mediated by medullary thymic epithelial cells (mTECs) which produce and present self-antigens to eliminate self-reactive T-cells or to redirect their development to the T-regulatory cell (Treg) lineage. To enhance the scope of self-antigen presentation, activated thymic dendritic cells (DCs) can highjack antigens from apoptotic mTECs and present them to developing T-cells. While this process which is known as cooperative antigens transfer (CAT) is indispensible for the establishment of central tolerance, the identity and function of other cell subsets involved in this mechanism remain unclear. Our preliminary data provides unambiguous evidence that NK and/or NKT cells which reside with mTECs and DCs in the thymic medulla, are vital for the activation of DCs, regulation of mTEC fate, affect CAT and the generation of Tregs. We propose to address the questions surrounding the role of NK/NKT cells in the regulation of central tolerance and prevention of autoimmunity.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30102 - Immunology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EC - Imunologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP24-GA0-GA-R
Datum dodání záznamu
19. 2. 2024

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