The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C > T; Pro319Ser) in women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002513" target="_blank" >RIV/00023001:_____/11:00002513 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C > T; Pro319Ser) in women

Popis výsledku v původním jazyce

Aim. The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women. Methods: A 5% population sampleof urban women aged 4554 years (N.=896) and a 1% representative sample of rural women aged 33-72 years (N.=152) were examined using an identical protocol and genotyped for Cx37 gene polymorphism. The association between the Cx37 polymorphism and intima-media thickness in common carotid arteries measured by ultrasound (CIMT) was studied. Results. We have found a different pattern of the effect of the Cx37 gene on CIMT with regard to fasting glycemia with significant interaction between fasting glycemia and Cx37 gene on CIMT (test for equality of slopes P<0.0001). In addition, we also detected potential threshold effect of fasting glycemia at the concentration of 5.5 mmol/L (AN-COVA; P=0.026). Carriers of TT genotype showed protection aga

Název v anglickém jazyce

The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C > T; Pro319Ser) in women

Popis výsledku anglicky

Aim. The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women. Methods: A 5% population sampleof urban women aged 4554 years (N.=896) and a 1% representative sample of rural women aged 33-72 years (N.=152) were examined using an identical protocol and genotyped for Cx37 gene polymorphism. The association between the Cx37 polymorphism and intima-media thickness in common carotid arteries measured by ultrasound (CIMT) was studied. Results. We have found a different pattern of the effect of the Cx37 gene on CIMT with regard to fasting glycemia with significant interaction between fasting glycemia and Cx37 gene on CIMT (test for equality of slopes P<0.0001). In addition, we also detected potential threshold effect of fasting glycemia at the concentration of 5.5 mmol/L (AN-COVA; P=0.026). Carriers of TT genotype showed protection aga

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NR9026" target="_blank" >NR9026: Genetická predisposice k cévním komplikacím diabetes mellitus 1. a 2. typu u žen</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

6

Strana od-do

221-226

Kód UT WoS článku

000293497400003

EID výsledku v databázi Scopus

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