Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2012_001" target="_blank" >10.4149/BLL_2012_001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats

Popis výsledku v původním jazyce

Objectves: We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats. Methods: Lewis iliolumbar veins were implanted into the abdominal aorta of isogeneic rats. Animals in the treatment groups had daily intramuscular injections of tacrolimus at 0.2 mg/kg (group B) and 0.1 mg/kg (Group C), respectively. The control group A had no treatment. Light microscope evaluations of arterialised vein grafts were performed 30 days after operation. We determined the presence of endothelial cells, the thickness of intima and media, and the degree of infiltration by MHC class II positive, CD4 positive, and CD8 positive cells into the adventitia. Results: The intimal thickness in group B (5.0 +/- 1.0 mu m) was statistically lower (P < 0.05) when compared to group C (7.0 +/- 3.0 mu m). The intimal thickness in untreated group A (12.7 +/- 7.0 mu m) was statistically higher (P < 0.01) when compared to both treated groups B and C, respectively. The medi

Název v anglickém jazyce

Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats

Popis výsledku anglicky

Objectves: We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats. Methods: Lewis iliolumbar veins were implanted into the abdominal aorta of isogeneic rats. Animals in the treatment groups had daily intramuscular injections of tacrolimus at 0.2 mg/kg (group B) and 0.1 mg/kg (Group C), respectively. The control group A had no treatment. Light microscope evaluations of arterialised vein grafts were performed 30 days after operation. We determined the presence of endothelial cells, the thickness of intima and media, and the degree of infiltration by MHC class II positive, CD4 positive, and CD8 positive cells into the adventitia. Results: The intimal thickness in group B (5.0 +/- 1.0 mu m) was statistically lower (P < 0.05) when compared to group C (7.0 +/- 3.0 mu m). The intimal thickness in untreated group A (12.7 +/- 7.0 mu m) was statistically higher (P < 0.01) when compared to both treated groups B and C, respectively. The medi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

113

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

5-9

Kód UT WoS článku

000299665400001

EID výsledku v databázi Scopus

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