The minimal dose of FK506 is sufficient to facilitate the arterialisation of venous allografts in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058657" target="_blank" >RIV/00023001:_____/13:00058657 - isvavai.cz</a>

Výsledek na webu

<a href="http://download.springer.com/static/pdf/4/art%253A10.1007%252Fs10353-012-0179-3.pdf?auth66=1387707005_8145352df6c7ee8a18b39cf19059a6d0&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/4/art%253A10.1007%252Fs10353-012-0179-3.pdf?auth66=1387707005_8145352df6c7ee8a18b39cf19059a6d0&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10353-012-0179-3" target="_blank" >10.1007/s10353-012-0179-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The minimal dose of FK506 is sufficient to facilitate the arterialisation of venous allografts in rats

Popis výsledku v původním jazyce

We investigated whether a minimal dose of FK506 is sufficient to inhibit the rejection of venous allografts and facilitate allograft adaptation to arterialisation in rats. Iliolumbar veins from Brown Norway (BN) rats were transplanted into the abdominalaorta of Lewis (LEW) rats. Recipient animals received daily intramuscular injections of 0.1 mg kg(-) (1) FK506. Light microscope evaluations of grafts were performed 30 days after transplantation. We investigated the presence of endothelial cells, the intensity of intimal proliferation, the deposition of immunoglobulin G molecules into the medial layer and the degree of adventitial infiltration by Lewis MHC class II-positive, CD4-positive and CD8-positive cells. All results were compared to previously reported data for syngeneic, allogeneic non-immunosuppressed and allogeneic FK506-low-dose immunosuppressed animals. All alloveins under minimal FK506 immunosuppression showed typical histological signs of arterialisation 30 days after tra

Název v anglickém jazyce

The minimal dose of FK506 is sufficient to facilitate the arterialisation of venous allografts in rats

Popis výsledku anglicky

We investigated whether a minimal dose of FK506 is sufficient to inhibit the rejection of venous allografts and facilitate allograft adaptation to arterialisation in rats. Iliolumbar veins from Brown Norway (BN) rats were transplanted into the abdominalaorta of Lewis (LEW) rats. Recipient animals received daily intramuscular injections of 0.1 mg kg(-) (1) FK506. Light microscope evaluations of grafts were performed 30 days after transplantation. We investigated the presence of endothelial cells, the intensity of intimal proliferation, the deposition of immunoglobulin G molecules into the medial layer and the degree of adventitial infiltration by Lewis MHC class II-positive, CD4-positive and CD8-positive cells. All results were compared to previously reported data for syngeneic, allogeneic non-immunosuppressed and allogeneic FK506-low-dose immunosuppressed animals. All alloveins under minimal FK506 immunosuppression showed typical histological signs of arterialisation 30 days after tra

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European surgery

ISSN

1682-8631

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

8-14

Kód UT WoS článku

000315446600003

EID výsledku v databázi Scopus

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