Variants within HNF1 alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00057937" target="_blank" >RIV/00023001:_____/12:00057937 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nel.edu/home.htm" target="_blank" >http://www.nel.edu/home.htm</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Variants within HNF1 alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study

Popis výsledku v původním jazyce

BACKGROUND: Atherosclerosis is a complex arterial disease involving interactions between multiple genetic and environmental factors. A large number of genetic polymorphisms associated with atherosclerotic diseases have been identified in recent years. Weinvestigated the possible association between hepatic nuclear factor (HNF1-alpha) and angiopoietin-like 4 (ANGPTL4) single nucleotide polymorphisms and the risk of acute coronary syndrome (ACS) in the Czech population. MATERIALS AND METHODS: A total of1,182 patients with ACS (835 males and 347 females) and 1,200 healthy controls (827 males and 373 females) were included in the study. All patients were younger than 65 years of age. rs7310409 (A>G within the HNF1-alpha gene) and rs116843064 (G>A withinthe ANGPTL4 gene) were genotyped using TaqMan genotyping assays. RESULTS: The frequencies of the genotypes in patients with ACS did not significantly differ from the control group for the rs7310409 polymorphism (AA=17.1%, AG=46.6%, GG=36.

Název v anglickém jazyce

Variants within HNF1 alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study

Popis výsledku anglicky

BACKGROUND: Atherosclerosis is a complex arterial disease involving interactions between multiple genetic and environmental factors. A large number of genetic polymorphisms associated with atherosclerotic diseases have been identified in recent years. Weinvestigated the possible association between hepatic nuclear factor (HNF1-alpha) and angiopoietin-like 4 (ANGPTL4) single nucleotide polymorphisms and the risk of acute coronary syndrome (ACS) in the Czech population. MATERIALS AND METHODS: A total of1,182 patients with ACS (835 males and 347 females) and 1,200 healthy controls (827 males and 373 females) were included in the study. All patients were younger than 65 years of age. rs7310409 (A>G within the HNF1-alpha gene) and rs116843064 (G>A withinthe ANGPTL4 gene) were genotyped using TaqMan genotyping assays. RESULTS: The frequencies of the genotypes in patients with ACS did not significantly differ from the control group for the rs7310409 polymorphism (AA=17.1%, AG=46.6%, GG=36.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

suppl. 2

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

4

Strana od-do

13-16

Kód UT WoS článku

000312175400004

EID výsledku v databázi Scopus

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