Cellular mechanisms of medium-chain chlorinated paraffins toxicity: the effect of cellular lipid content

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085689" target="_blank" >RIV/00023001:_____/25:00085689 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/25:43931475

Výsledek na webu

<a href="https://www.tandfonline.com/doi/epdf/10.1080/15376516.2025.2481909?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/epdf/10.1080/15376516.2025.2481909?needAccess=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15376516.2025.2481909" target="_blank" >10.1080/15376516.2025.2481909</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cellular mechanisms of medium-chain chlorinated paraffins toxicity: the effect of cellular lipid content

Popis výsledku v původním jazyce

Research on chlorinated paraffins (CPs) is growing, with accumulating evidence of CPs being present in biological matrices and animal tissues. However, their cellular-level impacts remain underexplored. This study investigates the effects of medium-chain CPs on adipose and liver cell models. The results show that CPs are more toxic at lower concentrations in 3T3-L1 preadipocytes than in adipocytes, suggesting that intracellular lipids may offer protection against these contaminants. However, neither simulated lipolysis in adipocytes nor lipogenesis in HepG2 hepatocytes revealed any lipid-dependent effects of CPs. CP exposure reduced heme oxygenase 1 expression, indicating a biological response to these contaminants. In a coculture model of adipocytes and macrophages, CP exposure influenced cell signaling, with lipid-rich adipocytes modulating macrophage immune responses. Our results demonstrate that medium-chain CPs accumulation in lipid-rich tissues does not significantly affect their toxic effects. However, it may influence cell signaling within adipose tissue.

Název v anglickém jazyce

Cellular mechanisms of medium-chain chlorinated paraffins toxicity: the effect of cellular lipid content

Popis výsledku anglicky

Research on chlorinated paraffins (CPs) is growing, with accumulating evidence of CPs being present in biological matrices and animal tissues. However, their cellular-level impacts remain underexplored. This study investigates the effects of medium-chain CPs on adipose and liver cell models. The results show that CPs are more toxic at lower concentrations in 3T3-L1 preadipocytes than in adipocytes, suggesting that intracellular lipids may offer protection against these contaminants. However, neither simulated lipolysis in adipocytes nor lipogenesis in HepG2 hepatocytes revealed any lipid-dependent effects of CPs. CP exposure reduced heme oxygenase 1 expression, indicating a biological response to these contaminants. In a coculture model of adipocytes and macrophages, CP exposure influenced cell signaling, with lipid-rich adipocytes modulating macrophage immune responses. Our results demonstrate that medium-chain CPs accumulation in lipid-rich tissues does not significantly affect their toxic effects. However, it may influence cell signaling within adipose tissue.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology Mechanisms and Methods

ISSN

1537-6516

e-ISSN

1537-6524

Svazek periodika

35

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

"655–667"

Kód UT WoS článku

001455451800001

EID výsledku v databázi Scopus

2-s2.0-105001982985