Spatial navigation in virtual reality - from animal models towards schizophrenia Spatial cognition tests based on animal research

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/67985823:_____/15:00471327 RIV/00216208:11120/15:43912237

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Spatial navigation in virtual reality - from animal models towards schizophrenia Spatial cognition tests based on animal research

Popis výsledku v původním jazyce

Schizophrenia is manifested in positive, negative and cognitive symptoms. Especially, the cognitive symptoms offer useful methodological approach for comparative studies using spatial navigation tasks in both, schizophrenia patients and animal models of cognitive deficit in schizophrenia. In order to demonstrate the deficit of spatial cognition in schizophrenia and to test the validity of pharmacological model, we designed two virtual tasks inspired by previous animal research: the virtual Morris water maze and Carousel maze. The newly-designed tasks require the tested subject to navigate toward several hidden goal positions placed on the floor of an enclosed stable arena or on a rotating arena. Data obtained in a group of schizophrenia patients and matched group of healthy volunteers show cognitive impairment in first episodes of schizophrenia using both, standardized neurocognitive methods and newly-developed virtual tests. The virtual test batteries show different involvement of navigation strategies and different level of impairment in schizophrenia patients. These findings indicate usefulness of these virtual methods in future cognitive remediation. Despite the fact, that both virtual tasks test spatial navigation towards hidden goal, obtained results are divided into partly different clusters using PCA, while performance parameters measured in the stable arena form a cluster mostly with tests of memory and executive functions; the rotating arena seems to he more related to performance tests dependent on timing, psychomotor speed and mental flexibility.

Název v anglickém jazyce

Spatial navigation in virtual reality - from animal models towards schizophrenia Spatial cognition tests based on animal research

Popis výsledku anglicky

Schizophrenia is manifested in positive, negative and cognitive symptoms. Especially, the cognitive symptoms offer useful methodological approach for comparative studies using spatial navigation tasks in both, schizophrenia patients and animal models of cognitive deficit in schizophrenia. In order to demonstrate the deficit of spatial cognition in schizophrenia and to test the validity of pharmacological model, we designed two virtual tasks inspired by previous animal research: the virtual Morris water maze and Carousel maze. The newly-designed tasks require the tested subject to navigate toward several hidden goal positions placed on the floor of an enclosed stable arena or on a rotating arena. Data obtained in a group of schizophrenia patients and matched group of healthy volunteers show cognitive impairment in first episodes of schizophrenia using both, standardized neurocognitive methods and newly-developed virtual tests. The virtual test batteries show different involvement of navigation strategies and different level of impairment in schizophrenia patients. These findings indicate usefulness of these virtual methods in future cognitive remediation. Despite the fact, that both virtual tasks test spatial navigation towards hidden goal, obtained results are divided into partly different clusters using PCA, while performance parameters measured in the stable arena form a cluster mostly with tests of memory and executive functions; the rotating arena seems to he more related to performance tests dependent on timing, psychomotor speed and mental flexibility.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

International Conference on Virtual Rehabilitation Proceedings (ICVR)

ISBN

978-1-4799-8984-3

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

44-50

Název nakladatele

IEEE, NEW YORK, USA

Místo vydání

Valencia, SPAIN

Místo konání akce

Valencia, SPAIN

Datum konání akce

9. 6. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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