Virtual spatial navigation tests based on animal research: spatial cognition deficit in first episodes of schizophrenia

Kód výsledku v IS VaVaI

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Virtual spatial navigation tests based on animal research: spatial cognition deficit in first episodes of schizophrenia

Popis výsledku v původním jazyce

The impairment of cognitive functions represents a characteristic manifestation in schizophrenia and related psychotic disorders, together with positive and negative symptoms. Cognitive symptoms offer very useful methodological approach for comparative studies in schizophrenia research. Both animal models of schizophrenia and schizophrenia patients have demonstrated behavioral changes in several spatial navigation tasks; assessment of spatial cognition can be therefore applied in comparative studies. In order to demonstrate the deficit of spatial cognition in schizophrenia, and to test the validity of pharmacological animal models of schizophrenia, we designed two virtual navigation tasks inspired by previous animal research: the virtual Morris water maze and the virtual Carousel maze. Both virtual tests consisting of four phases have been tested in a group of 30 first episode schizophrenia patients and a group of healthy volunteers matched for age, sex and education. In both tests, subjects were required to navigate towards several hidden goal positions placed on the floor of an enclosed stable arena or a rotating arena. Data obtained using these virtual tests show a decline in the cognitive performance of schizophrenia patients in comparison to matched healthy volunteers. Our findings support the validity of the animal model of cognitive deficit in schizophrenia and the presence of impaired cognitive functions in schizophrenia patients.

Název v anglickém jazyce

Virtual spatial navigation tests based on animal research: spatial cognition deficit in first episodes of schizophrenia

Popis výsledku anglicky

The impairment of cognitive functions represents a characteristic manifestation in schizophrenia and related psychotic disorders, together with positive and negative symptoms. Cognitive symptoms offer very useful methodological approach for comparative studies in schizophrenia research. Both animal models of schizophrenia and schizophrenia patients have demonstrated behavioral changes in several spatial navigation tasks; assessment of spatial cognition can be therefore applied in comparative studies. In order to demonstrate the deficit of spatial cognition in schizophrenia, and to test the validity of pharmacological animal models of schizophrenia, we designed two virtual navigation tasks inspired by previous animal research: the virtual Morris water maze and the virtual Carousel maze. Both virtual tests consisting of four phases have been tested in a group of 30 first episode schizophrenia patients and a group of healthy volunteers matched for age, sex and education. In both tests, subjects were required to navigate towards several hidden goal positions placed on the floor of an enclosed stable arena or a rotating arena. Data obtained using these virtual tests show a decline in the cognitive performance of schizophrenia patients in comparison to matched healthy volunteers. Our findings support the validity of the animal model of cognitive deficit in schizophrenia and the presence of impaired cognitive functions in schizophrenia patients.

Druh

C - Kapitola v odborné knize

CEP obor

AN - Psychologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Recent Advances on Using Virtual Reality Technologies for Rehabilitation

ISBN

978-1-63484-027-9

Počet stran výsledku

12

Strana od-do

111-122

Počet stran knihy

196

Název nakladatele

Nova Science Publishers

Místo vydání

New York

Kód UT WoS kapitoly

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