PARTICLE - The RNA podium for genomic silencers

Kód výsledku v IS VaVaI

RIV/00023752:_____/19:43919852 - isvavai.cz

Nalezeny alternativní kódy

RIV/00216208:11120/19:43918223

Výsledek na webu

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28739

DOI - Digital Object Identifier

10.1002/jcp.28739

Jazyk výsledku

angličtina

Název v původním jazyce

PARTICLE - The RNA podium for genomic silencers

Popis výsledku v původním jazyce

Radiation exposure can evoke cellular stress responses. Emerging recognition that long non‐coding RNAs (lncRNAs) act as regulators of gene expression has broadened the spectra of molecules controlling the genomic landscape upon alterations in environmental conditions. Knowledge of the mechanisms responding to low dose irradiation (LDR) exposure is very limited yet most likely involve subtle ancillary molecular pathways other than those protecting the cell from direct cellular damage. The discovery that transcription of the lncRNA PARTICLE (promoter of MAT2A‐ antisense radiation‐induced circulating lncRNA; PARTICL) becomes dramatically instigated within a day after LDR exposure introduced a new gene regulator onto the biological landscape. PARTICLE affords an RNA binding platform for genomic silencers such as DNA methyltransferase 1 and histone tri‐methyltransferases to reign in the expression of tumor suppressors such as its neighboring MAT2A in cis as well as WWOX in trans. In silico evidence offers scope to speculate that PARTICLE exploits the abundance of Hoogsten bonds that exist throughout mammalian genomes for triplex formation, presumably a vital feature within this RNA silencer. PARTICLE may provide a buffering riboswitch platform for S‐adenosylmethionine. The correlation of PARTICLE triplex formation sites within tumor suppressor genes and their abundance throughout the genome at cancer‐related hotspots offers an insight into potential avenues worth exploring in future therapeutic endeavors.

Název v anglickém jazyce

PARTICLE - The RNA podium for genomic silencers

Popis výsledku anglicky

Radiation exposure can evoke cellular stress responses. Emerging recognition that long non‐coding RNAs (lncRNAs) act as regulators of gene expression has broadened the spectra of molecules controlling the genomic landscape upon alterations in environmental conditions. Knowledge of the mechanisms responding to low dose irradiation (LDR) exposure is very limited yet most likely involve subtle ancillary molecular pathways other than those protecting the cell from direct cellular damage. The discovery that transcription of the lncRNA PARTICLE (promoter of MAT2A‐ antisense radiation‐induced circulating lncRNA; PARTICL) becomes dramatically instigated within a day after LDR exposure introduced a new gene regulator onto the biological landscape. PARTICLE affords an RNA binding platform for genomic silencers such as DNA methyltransferase 1 and histone tri‐methyltransferases to reign in the expression of tumor suppressors such as its neighboring MAT2A in cis as well as WWOX in trans. In silico evidence offers scope to speculate that PARTICLE exploits the abundance of Hoogsten bonds that exist throughout mammalian genomes for triplex formation, presumably a vital feature within this RNA silencer. PARTICLE may provide a buffering riboswitch platform for S‐adenosylmethionine. The correlation of PARTICLE triplex formation sites within tumor suppressor genes and their abundance throughout the genome at cancer‐related hotspots offers an insight into potential avenues worth exploring in future therapeutic endeavors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cellular Physiology

ISSN

0021-9541

e-ISSN

—

Svazek periodika

234

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

19464-19470

Kód UT WoS článku

000478018200030

EID výsledku v databázi Scopus

2-s2.0-85065430770