The relationships between cognitive reserve, cognitive functioning and quality of life in first-episode schizophrenia spectrum disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920802" target="_blank" >RIV/00023752:_____/22:43920802 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10441065 RIV/00216208:11120/22:43923036 RIV/00216208:11210/22:10441065

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0165178122000932?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165178122000932?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psychres.2022.114479" target="_blank" >10.1016/j.psychres.2022.114479</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The relationships between cognitive reserve, cognitive functioning and quality of life in first-episode schizophrenia spectrum disorders

Popis výsledku v původním jazyce

Cognitive reserve (CR) has been conceptualized as an individual’s ability to optimize or maximize performance through differential recruitment of brain networks. As such, CR may contribute to the heterogeneity of cognitive deficits observed in schizophrenia. This study aimed to assess the relationships between CR, cognition and quality of life in first-episode (FES) patients. A total of 137 patients with either ICD-10 schizophrenia or “acute and transient psychotic disorders” diagnosis, and 62 healthy controls had completed a comprehensive assessment of six cognitive domains: speed of processing, attention, working memory/flexibility, verbal memory, visual memory, and abstraction/executive functioning. CR was calculated from the participants’ education, premorbid IQ, and socioeconomic status. The results suggested that in patients, CR was positively related to cognitive performance in all domains, explaining 42.6% of the variance observed in cognition overall. Effects of CR in the control group were limited to three domains: speed of processing, abstraction/executive function and working memory/flexibility. These results suggest that CR largely contributes to cognitive variations present in FES patients. In addition, CR was negatively related to the social construct of patients’ quality of life, and positively to symptom severity and general functioning.

Název v anglickém jazyce

The relationships between cognitive reserve, cognitive functioning and quality of life in first-episode schizophrenia spectrum disorders

Popis výsledku anglicky

Cognitive reserve (CR) has been conceptualized as an individual’s ability to optimize or maximize performance through differential recruitment of brain networks. As such, CR may contribute to the heterogeneity of cognitive deficits observed in schizophrenia. This study aimed to assess the relationships between CR, cognition and quality of life in first-episode (FES) patients. A total of 137 patients with either ICD-10 schizophrenia or “acute and transient psychotic disorders” diagnosis, and 62 healthy controls had completed a comprehensive assessment of six cognitive domains: speed of processing, attention, working memory/flexibility, verbal memory, visual memory, and abstraction/executive functioning. CR was calculated from the participants’ education, premorbid IQ, and socioeconomic status. The results suggested that in patients, CR was positively related to cognitive performance in all domains, explaining 42.6% of the variance observed in cognition overall. Effects of CR in the control group were limited to three domains: speed of processing, abstraction/executive function and working memory/flexibility. These results suggest that CR largely contributes to cognitive variations present in FES patients. In addition, CR was negatively related to the social construct of patients’ quality of life, and positively to symptom severity and general functioning.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50103 - Cognitive sciences

Projekt

<a href="/cs/project/GA21-03615S" target="_blank" >GA21-03615S: Vztah kognice ke kognitivní a mozkové rezervě u prvních epizod onemocnění schizofrenního spektra: prospektivní studie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatry Research

ISSN

0165-1781

e-ISSN

—

Svazek periodika

310

Číslo periodika v rámci svazku

"Article Number: 114479"

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

9

Strana od-do

1-9

Kód UT WoS článku

000829452000040

EID výsledku v databázi Scopus

2-s2.0-85125247121