Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations with Measurements on Rat Head Phantoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920924" target="_blank" >RIV/00023752:_____/22:43920924 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/22:PU145760

Výsledek na webu

<a href="https://ieeexplore.ieee.org/document/9868355/" target="_blank" >https://ieeexplore.ieee.org/document/9868355/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/ACCESS.2022.3202206" target="_blank" >10.1109/ACCESS.2022.3202206</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations with Measurements on Rat Head Phantoms

Popis výsledku v původním jazyce

In the paper, we propose a procedure to be used for the validation of software for forward modeling of rat electroencephalogram with scalp potentials measured on rat head phantoms. Measurements are performed on a cuboidal phantom, a simplified shape of a rat brain, and an anatomically realistic, computed tomography (CT)-based phantom considering the brain and the skull. The physical phantoms are composed of an agar mixture to mimic the rat brain, excitation dipoles for modeling the neural activity of the brain, electrodes for monitoring the surface electric potential and a 3D printed skull. To ensure correct positions of dipoles and electrodes for numerical simulations, the phantoms are scanned by a computed tomography. After that, reconstructed 3D models are simulated in three EM solvers and results are compared with EEG measurements. Differences between simulations and measurements are further analyzed by parametric simulations and discussed. Obtained results provide the software validation method for rat brain forward modeling. Properly validated computation of electric potentials is essential for development of electrical brain stimulation protocols as well as in optimization of electrode placement.

Název v anglickém jazyce

Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations with Measurements on Rat Head Phantoms

Popis výsledku anglicky

In the paper, we propose a procedure to be used for the validation of software for forward modeling of rat electroencephalogram with scalp potentials measured on rat head phantoms. Measurements are performed on a cuboidal phantom, a simplified shape of a rat brain, and an anatomically realistic, computed tomography (CT)-based phantom considering the brain and the skull. The physical phantoms are composed of an agar mixture to mimic the rat brain, excitation dipoles for modeling the neural activity of the brain, electrodes for monitoring the surface electric potential and a 3D printed skull. To ensure correct positions of dipoles and electrodes for numerical simulations, the phantoms are scanned by a computed tomography. After that, reconstructed 3D models are simulated in three EM solvers and results are compared with EEG measurements. Differences between simulations and measurements are further analyzed by parametric simulations and discussed. Obtained results provide the software validation method for rat brain forward modeling. Properly validated computation of electric potentials is essential for development of electrical brain stimulation protocols as well as in optimization of electrode placement.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/GA18-16218S" target="_blank" >GA18-16218S: Elektromagnetické modely zvířecích mozků</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IEEE Access

ISSN

2169-3536

e-ISSN

2169-3536

Svazek periodika

10

Číslo periodika v rámci svazku

22029828

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

92023-92035

Kód UT WoS článku

000852219300001

EID výsledku v databázi Scopus

2-s2.0-85137610037