Vliv genisteinu a genistinu na dozrávání prasečích oocytů in vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F08%3A%230000800" target="_blank" >RIV/00027014:_____/08:#0000800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/08:25732

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of genistein and genistin on in vitro maturation of pig oocytes

Popis výsledku v původním jazyce

The effects of GEN (genistein ? an inhibitor of tyrosine protein kinase ? TPK) and GIN (genistin, an analogue of GEN without effects on TPK) on pig oocyte maturation and cumular cell expansion under in vitro conditions and connection with their estrogenic activity were tested. Further, the reversibility of GEN effects was verified. GEN blocked pig oocyte maturation at the stage of the germinal vesicle (GV), depending on the dose. After rinsing out the GEN the oocyte maturation recovered, but with abnormalities. As for GIN, with an increase in its concentration, the number of oocytes blocked at the GV stage significantly decreased, but the abnormal maturation increased. GEN inhibited the cumular cell expansion in proportion to its dose. GIN had a less pronounced effect. As GEN and GIN effects demonstrate similar patterns, it is probable that estrogenic activity is involved.

Název v anglickém jazyce

Effects of genistein and genistin on in vitro maturation of pig oocytes

Popis výsledku anglicky

The effects of GEN (genistein ? an inhibitor of tyrosine protein kinase ? TPK) and GIN (genistin, an analogue of GEN without effects on TPK) on pig oocyte maturation and cumular cell expansion under in vitro conditions and connection with their estrogenic activity were tested. Further, the reversibility of GEN effects was verified. GEN blocked pig oocyte maturation at the stage of the germinal vesicle (GV), depending on the dose. After rinsing out the GEN the oocyte maturation recovered, but with abnormalities. As for GIN, with an increase in its concentration, the number of oocytes blocked at the GV stage significantly decreased, but the abnormal maturation increased. GEN inhibited the cumular cell expansion in proportion to its dose. GIN had a less pronounced effect. As GEN and GIN effects demonstrate similar patterns, it is probable that estrogenic activity is involved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GD523%2F03%2FH076" target="_blank" >GD523/03/H076: Zvýšení metodologické úrovně a teoretického vzdělání studentů akreditovaného DSP 4103V Zootechnika - perspektivního stud. oboru obecná zootechnika</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czech Journal of Animal Science

ISSN

1212-1819

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000253027900001

EID výsledku v databázi Scopus

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