Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F13%3A%230001953" target="_blank" >RIV/00027014:_____/13:#0001953 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/13182.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/13182.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose

Popis výsledku v původním jazyce

Hypercholesterolemia and obesity belong to the main risk factors of coronary heart disease, which is the leading cause of deaths worldwide. Several methods for the treatment of hypercholesterolemia exist, mainly fat restriction, the use of inhibitors of3-hydroxy-3-methylglutaryl-CoA reductase (statins), and sequestrans that bind bile acids in the small intestine and interrupt their enterohepatic circulation (Stedronsky, 1994). Increased conversion of cholesterol to bile acids in the liver compensates for the loss of bile acids in faeces, which results in reduction of cholesterolemia. An alternative to bile acid sequestrants are sorbents of sterols prepared by amidation of polysaccharides. In our recent study, the hypocholesterolemic effect of octadecylpectinamide was examined in rats fed diets containing cholesterol at 10 g for kg (Marounek et al., 2013). Amidated pectin supplied at 20, 40 and 60g for kg significantly decreased serum cholesterol from 3.32 (control) to 1.23 mikromol fo

Název v anglickém jazyce

Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose

Popis výsledku anglicky

Hypercholesterolemia and obesity belong to the main risk factors of coronary heart disease, which is the leading cause of deaths worldwide. Several methods for the treatment of hypercholesterolemia exist, mainly fat restriction, the use of inhibitors of3-hydroxy-3-methylglutaryl-CoA reductase (statins), and sequestrans that bind bile acids in the small intestine and interrupt their enterohepatic circulation (Stedronsky, 1994). Increased conversion of cholesterol to bile acids in the liver compensates for the loss of bile acids in faeces, which results in reduction of cholesterolemia. An alternative to bile acid sequestrants are sorbents of sterols prepared by amidation of polysaccharides. In our recent study, the hypocholesterolemic effect of octadecylpectinamide was examined in rats fed diets containing cholesterol at 10 g for kg (Marounek et al., 2013). Amidated pectin supplied at 20, 40 and 60g for kg significantly decreased serum cholesterol from 3.32 (control) to 1.23 mikromol fo

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 9th International Conference on Polysaccharides-Glycoscience

ISBN

978-80-86238-58-6

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

159-161

Název nakladatele

Czech Chemical Society, Novotneho Lavka 5, Prague, Czech Republic

Místo vydání

Prague

Místo konání akce

Prague

Datum konání akce

6. 11. 2013

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000341216900039