Comparative Study on the Hypocholesterolemic Activity of Amidated Polysaccharides and Psyllium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F16%3AN0000001" target="_blank" >RIV/00027014:_____/16:N0000001 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/16:70328

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/16001.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/16001.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15376/biores.11.1.365-372" target="_blank" >10.15376/biores.11.1.365-372</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative Study on the Hypocholesterolemic Activity of Amidated Polysaccharides and Psyllium

Popis výsledku v původním jazyce

The effects of amidated carboxymethylcellulose, amidated pectin, and psyllium on serum and hepatic cholesterol, hepatic fat, and fecal output of sterols were examined in female rats. Rats were fed a diet supplemented with cholesterol (0 or 10 g/kg) and palm fat. Amidated cellulose at 30 g/kg significantly decreased the serum and hepatic concentration of cholesterol by 28.1% and 64.6%, respectively. Corresponding values in rats fed amidated pectin were 28.9% and 72.4%. The effects of psyllium were similar, but less pronounced. Amidated pectin significantly increased the fecal output of cholesterol, total neutral sterols, and total sterols by 49.1%, 31.9%, and 31.0%, respectively. Amidated cellulose and psyllium increased the fecal excretion of total sterols by 1.1% and 5.5%, respectively. In the feces of rats fed amidated cellulose, a small amount of conjugated bile acids was detected (0.83% of total bile acids). In these rats, the lowest expression of hepatic cholesterol 7a-hydroxylase was detected, corresponding to the low fecal output of bile acids. We conclude that the hypocholesterolemic effects of both amidated polysaccharides were similar in spite of their different affinity to sterols

Název v anglickém jazyce

Comparative Study on the Hypocholesterolemic Activity of Amidated Polysaccharides and Psyllium

Popis výsledku anglicky

The effects of amidated carboxymethylcellulose, amidated pectin, and psyllium on serum and hepatic cholesterol, hepatic fat, and fecal output of sterols were examined in female rats. Rats were fed a diet supplemented with cholesterol (0 or 10 g/kg) and palm fat. Amidated cellulose at 30 g/kg significantly decreased the serum and hepatic concentration of cholesterol by 28.1% and 64.6%, respectively. Corresponding values in rats fed amidated pectin were 28.9% and 72.4%. The effects of psyllium were similar, but less pronounced. Amidated pectin significantly increased the fecal output of cholesterol, total neutral sterols, and total sterols by 49.1%, 31.9%, and 31.0%, respectively. Amidated cellulose and psyllium increased the fecal excretion of total sterols by 1.1% and 5.5%, respectively. In the feces of rats fed amidated cellulose, a small amount of conjugated bile acids was detected (0.83% of total bile acids). In these rats, the lowest expression of hepatic cholesterol 7a-hydroxylase was detected, corresponding to the low fecal output of bile acids. We conclude that the hypocholesterolemic effects of both amidated polysaccharides were similar in spite of their different affinity to sterols

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioResources

ISSN

1930-2126

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

365-372

Kód UT WoS článku

000367732700031

EID výsledku v databázi Scopus

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