Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovinne mammary gland induced by lipopolysaccharide and muramyl dipeptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000490" target="_blank" >RIV/00027162:_____/09:#0000490 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovinne mammary gland induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku v původním jazyce

The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolised macrophages ((N)MAC) after 24 h. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+ (N)MAC. The lower total count and proportion of CD44 + vacuolised macrophages ((V)MAC) was observed as the effect of MDP and LPS at 24 h after induction (P<0.01). During resolution, the total count and proportion of CD44 + (V)MAC increased. We have demonstrated CD44 receptor is expressedduring the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response.

Název v anglickém jazyce

Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovinne mammary gland induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku anglicky

The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolised macrophages ((N)MAC) after 24 h. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+ (N)MAC. The lower total count and proportion of CD44 + vacuolised macrophages ((V)MAC) was observed as the effect of MDP and LPS at 24 h after induction (P<0.01). During resolution, the total count and proportion of CD44 + (V)MAC increased. We have demonstrated CD44 receptor is expressedduring the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F03%2F1531" target="_blank" >GA524/03/1531: Role mononukleárních fagocytů během rezoluce akutního zánětu mléčné žlázy skotu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research in Veterinary Science

ISSN

0034-5288

e-ISSN

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Svazek periodika

86

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000264244800009

EID výsledku v databázi Scopus

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