Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F09%3A00128002" target="_blank" >RIV/62156489:43210/09:00128002 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.rvsc.2008.07.016" target="_blank" >http://dx.doi.org/10.1016/j.rvsc.2008.07.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rvsc.2008.07.016" target="_blank" >10.1016/j.rvsc.2008.07.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku v původním jazyce

The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolized macrophages (NMAC) after 24 hours. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+NMAC. The lower total count and proportion of CD44+ vacuolized macrophages (VMAC) was observed as the effect of MDP and LPS at 24 hours after induction (P<0.01). During resolution, the total count and proportion of CD44+VMAC increased. We have demonstrated CD44 receptor is expressed during the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response. High expression of CD44 in resolution of inflammatory respon

Název v anglickém jazyce

Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku anglicky

The aim of this study was to investigate development over time of the surface expression of CD44 on macrophages during an inflammatory response of bovine mammary gland. Intramammary instillation of muramyl dipeptide (MDP) and lipopolysaccharide (LPS) resulted in a significant increase in the total count of CD44+ non-vacuolized macrophages (NMAC) after 24 hours. During resolution of the inflammatory response, there was observed a gradual decrease in the total count CD44+NMAC. The lower total count and proportion of CD44+ vacuolized macrophages (VMAC) was observed as the effect of MDP and LPS at 24 hours after induction (P<0.01). During resolution, the total count and proportion of CD44+VMAC increased. We have demonstrated CD44 receptor is expressed during the inflammatory response caused by LPS and MDP and the effect of these components on CD44 expression was particularly evident during initiation of the inflammatory response. High expression of CD44 in resolution of inflammatory respon

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research in Veterinary Science

ISSN

0034-5288

e-ISSN

—

Svazek periodika

86

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

235-240

Kód UT WoS článku

264244800009

EID výsledku v databázi Scopus

—