Exprese receptoru CD14 na makrofágu během experimentální zánětlivé reakce indukované lipopolysacharidem a muramyl dipeptidem

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000389" target="_blank" >RIV/00027162:_____/08:#0000389 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku v původním jazyce

The aim of this study was to determine whether expression of CD14 on macrophages is regulated differently during initiation and resolution of the inflammatory response caused by CD14-dependent (lipopolysaccharide - LPS) and CD14-independent (muramyldipeptide - MDP) bacterial signals. Intramammary instillation of MDP and LPS resulted in a significant increase in the total count of CD14+ macrophages after 24 hours in contrast to phosphate buffered saline. During resolution of the inflammatory response, agradual decrease in the total count of CD14+ macrophages was observed. We therefore assume that the expression of CD14 on macrophages is not regulated differently during the inflammatory responses caused by CD14-dependent and CD14-independent bacterial signals. On the other hand, the stage of the inflammatory response to muramyldipeptide and lipopolysaccharide played an important role in the regulation of CD14 expression on macrophages.

Název v anglickém jazyce

Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide

Popis výsledku anglicky

The aim of this study was to determine whether expression of CD14 on macrophages is regulated differently during initiation and resolution of the inflammatory response caused by CD14-dependent (lipopolysaccharide - LPS) and CD14-independent (muramyldipeptide - MDP) bacterial signals. Intramammary instillation of MDP and LPS resulted in a significant increase in the total count of CD14+ macrophages after 24 hours in contrast to phosphate buffered saline. During resolution of the inflammatory response, agradual decrease in the total count of CD14+ macrophages was observed. We therefore assume that the expression of CD14 on macrophages is not regulated differently during the inflammatory responses caused by CD14-dependent and CD14-independent bacterial signals. On the other hand, the stage of the inflammatory response to muramyldipeptide and lipopolysaccharide played an important role in the regulation of CD14 expression on macrophages.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000258374200001

EID výsledku v databázi Scopus

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