Fertile bull sperm aneuploidy and chromatin integrity in relationship to fertility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F10%3A%230000606" target="_blank" >RIV/00027162:_____/10:#0000606 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fertile bull sperm aneuploidy and chromatin integrity in relationship to fertility

Popis výsledku v původním jazyce

The purpose of the study was to analyse frequency of aneuploidies of sex chromosomes and chromosome 6 by three-colour FISH in 47 young fertile bulls and to investigate the influence of aneuploidies and disturbed sperm chromatin integrity on non-return rates, the frequencies of abortions, perinatal mortality and stillbirths. Significant correlation was found between sex disomy, total aneuploidy (disomy of chromosomes 6, X, Y and XY sperm and diploidy) and stillbirths (r=0.390; P=0.013; and r=0.331; P=0.037), non-return rate and total aneuploidy (r=-0.310; P=0.036). Chromosome 6 disomy correlated with perinatal mortality (r=0.317; P=0.047). HDS correlated significantly with total aneuploidy (r=0.449; P=0.002). Our study indicated that aneuploidy frequencies in young fertile bull sperm are relatively low. Nevertheless, there exists a variability in aneuploidy frequencies amongst bulls, which appears to be able to have an influence on the fertility of these animals.

Název v anglickém jazyce

Fertile bull sperm aneuploidy and chromatin integrity in relationship to fertility

Popis výsledku anglicky

The purpose of the study was to analyse frequency of aneuploidies of sex chromosomes and chromosome 6 by three-colour FISH in 47 young fertile bulls and to investigate the influence of aneuploidies and disturbed sperm chromatin integrity on non-return rates, the frequencies of abortions, perinatal mortality and stillbirths. Significant correlation was found between sex disomy, total aneuploidy (disomy of chromosomes 6, X, Y and XY sperm and diploidy) and stillbirths (r=0.390; P=0.013; and r=0.331; P=0.037), non-return rate and total aneuploidy (r=-0.310; P=0.036). Chromosome 6 disomy correlated with perinatal mortality (r=0.317; P=0.047). HDS correlated significantly with total aneuploidy (r=0.449; P=0.002). Our study indicated that aneuploidy frequencies in young fertile bull sperm are relatively low. Nevertheless, there exists a variability in aneuploidy frequencies amongst bulls, which appears to be able to have an influence on the fertility of these animals.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Andrology

ISSN

0105-6263

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000279669200007

EID výsledku v databázi Scopus

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