Individuální variace ve frekvenci aneuploidií v lidských spermiích

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000026" target="_blank" >RIV/00027162:_____/05:06000026 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Individual variation in the frequency of sperm aneuploidy in humans

Popis výsledku v původním jazyce

To examine interindividual differences in sperm chromosome aneuploidy, repeated semen specimens were obtained from a group of ten healthy men, aged 20-21 at the start of the study, and analyzed by FISH to determine the frequencies of sperm aneuploidy forchromosomes X, Y, 8, 18 and 21 and of diploidy. Men were sampled three times over a 5-year period. Statistical analysis examining the stability of sperm aneuploidy over time by type and chromosome identified two men who consistently exhibited elevatedfrequencies of sperm aneuploidy. Overall, disomy frequencies were lower for chromosome X, 8 and 18 than for chromosomes 21 or Y and for XY aneuploidy. The frequency of chromosome Y disomy did not differ from XY sperm frequency. Frequencies of spermaneuploidy were similar between the first sampling period and the second, two years later. However, the frequency of some types of aneuploidy increased significantly between the first sampling period and the last, five years later.

Název v anglickém jazyce

Individual variation in the frequency of sperm aneuploidy in humans

Popis výsledku anglicky

To examine interindividual differences in sperm chromosome aneuploidy, repeated semen specimens were obtained from a group of ten healthy men, aged 20-21 at the start of the study, and analyzed by FISH to determine the frequencies of sperm aneuploidy forchromosomes X, Y, 8, 18 and 21 and of diploidy. Men were sampled three times over a 5-year period. Statistical analysis examining the stability of sperm aneuploidy over time by type and chromosome identified two men who consistently exhibited elevatedfrequencies of sperm aneuploidy. Overall, disomy frequencies were lower for chromosome X, 8 and 18 than for chromosomes 21 or Y and for XY aneuploidy. The frequency of chromosome Y disomy did not differ from XY sperm frequency. Frequencies of spermaneuploidy were similar between the first sampling period and the second, two years later. However, the frequency of some types of aneuploidy increased significantly between the first sampling period and the last, five years later.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytogenetic and Genome Research

ISSN

1424-8581

e-ISSN

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Svazek periodika

111

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

229-236

Kód UT WoS článku

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EID výsledku v databázi Scopus

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