Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000032" target="_blank" >RIV/00027162:_____/19:N0000032 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41467-019-08853-3" target="_blank" >https://www.nature.com/articles/s41467-019-08853-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-019-08853-3" target="_blank" >10.1038/s41467-019-08853-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Popis výsledku v původním jazyce

Antimicrobial resistance (AMR) is one of the largest global public health threats, but obtaining comparable data representing human healthy populations is difficult. We characterized the bacterial resistome in untreated sewage from 79 sites in 60 countries. We found a large variations in AMR gene abundance and diversity across the geographical sites and continents, with the largest AMR gene levels being observed in Africa and the lowest in Oceania, New Zealand and Australia. Data on antimicrobial use (AMU) and measured antimicrobial residues only explained a minor part of the AMR variation and no evidence for cross-selection between antimicrobial classes of effect of travel by flight between sites was observed. AMR abundance was strongly correlated with socio-economic, health and environmental factors, which we used to predict AMR in all countries in the world. Our findings suggest that even though AMR genes might rapidly disseminate globally, local selection is required to reach appreciable frequencies. Improving sanitation, health and perhaps education could potentially limit the global burden of AMR. We propose to use environmental surveillance as an ethically acceptable, and logistically and economically feasible approach to continuous global surveillance and prediction of AMR.

Název v anglickém jazyce

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Popis výsledku anglicky

Antimicrobial resistance (AMR) is one of the largest global public health threats, but obtaining comparable data representing human healthy populations is difficult. We characterized the bacterial resistome in untreated sewage from 79 sites in 60 countries. We found a large variations in AMR gene abundance and diversity across the geographical sites and continents, with the largest AMR gene levels being observed in Africa and the lowest in Oceania, New Zealand and Australia. Data on antimicrobial use (AMU) and measured antimicrobial residues only explained a minor part of the AMR variation and no evidence for cross-selection between antimicrobial classes of effect of travel by flight between sites was observed. AMR abundance was strongly correlated with socio-economic, health and environmental factors, which we used to predict AMR in all countries in the world. Our findings suggest that even though AMR genes might rapidly disseminate globally, local selection is required to reach appreciable frequencies. Improving sanitation, health and perhaps education could potentially limit the global burden of AMR. We propose to use environmental surveillance as an ethically acceptable, and logistically and economically feasible approach to continuous global surveillance and prediction of AMR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature communications

ISSN

2041-1723

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

MAR 2019

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1124

Kód UT WoS článku

000460631100009

EID výsledku v databázi Scopus

2-s2.0-85062620273