Modification of Liposomal Surface by Polysacharides: Preparation, Characterization and Appliccation for Drug Targeting – chapter 13

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000292" target="_blank" >RIV/00027162:_____/19:N0000292 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.elsevier.com/books/functional-polysaccharides-for-biomedical-applications/maiti/978-0-08-102555-0" target="_blank" >https://www.elsevier.com/books/functional-polysaccharides-for-biomedical-applications/maiti/978-0-08-102555-0</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Modification of Liposomal Surface by Polysacharides: Preparation, Characterization and Appliccation for Drug Targeting – chapter 13

Popis výsledku v původním jazyce

Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates and, dextrans are applied for preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is new challenging approach for development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for production of liposome-based products.

Název v anglickém jazyce

Modification of Liposomal Surface by Polysacharides: Preparation, Characterization and Appliccation for Drug Targeting – chapter 13

Popis výsledku anglicky

Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates and, dextrans are applied for preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is new challenging approach for development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for production of liposome-based products.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Functional Polysaccharides for Biomedical Applications

ISBN

9780081025550

Počet stran výsledku

35

Strana od-do

433-467

Počet stran knihy

526

Název nakladatele

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Místo vydání

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Kód UT WoS kapitoly

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