Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization and Application for Drug Targeting
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73593026" target="_blank" >RIV/61989592:15110/19:73593026 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/B9780081025550000133" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780081025550000133</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-08-102555-0.00013-3" target="_blank" >10.1016/B978-0-08-102555-0.00013-3</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization and Application for Drug Targeting
Popis výsledku v původním jazyce
Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates and, dextrans are applied for preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is new challenging approach for development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for production of liposome-based products.
Název v anglickém jazyce
Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization and Application for Drug Targeting
Popis výsledku anglicky
Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates and, dextrans are applied for preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is new challenging approach for development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for production of liposome-based products.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
—
OECD FORD obor
10404 - Polymer science
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Functional Polysaccharides for Biomedical Applications
ISBN
978-0-08-102555-0
Počet stran výsledku
35
Strana od-do
433-467
Počet stran knihy
526
Název nakladatele
Woodhead Publishing
Místo vydání
Anglie
Kód UT WoS kapitoly
—