Nanofibers in mucosal drug and vaccine delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000008" target="_blank" >RIV/00027162:_____/20:N0000008 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.intechopen.com/books/nanomaterials-toxicity-human-health-and-environment/nanofibers-in-mucosal-drug-and-vaccine-delivery" target="_blank" >https://www.intechopen.com/books/nanomaterials-toxicity-human-health-and-environment/nanofibers-in-mucosal-drug-and-vaccine-delivery</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/intechopen.82279" target="_blank" >10.5772/intechopen.82279</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanofibers in mucosal drug and vaccine delivery

Popis výsledku v původním jazyce

Successful mucosal administration and delivery of drugs still pose a great challenge. However, the possibility to deliver not only small drug molecules, but also macromolecular drugs and nanoparticles via mucosal surfaces represents a great opportunity. Rapid onset of drug action, avoidance of first-pass metabolism, and high immunocompetence of mucosa are some of the important features for mucosal drug and vaccine delivery. The use of mucoadhesive drug delivery systems, systems with fast-dissolving properties, and nanomaterials with mucus penetration properties are examples of successful strategies to achieve effective mucosal drug and vaccine delivery. Non-keratinised mucosa of the oral cavity, the nasal and vaginal mucosa represent favourable sites of drug administration. Polymer nanofibers have attracted much attention because of remarkable characteristics such as a large surface area to volume ratio and high porosity. Nanofibers have been extensively used for different biomedical applications including wound dressing, tissue engineering and drug delivery. Among their fabrication methods, the introduction of electrospinning technique was an important step towards achieving the goal of large scale industrial production of nanofiber-based drug delivery systems used in mucosal applications. This chapter provides an overview on all aspects of mucosal drug and vaccine delivery using nanofibers.

Název v anglickém jazyce

Nanofibers in mucosal drug and vaccine delivery

Popis výsledku anglicky

Successful mucosal administration and delivery of drugs still pose a great challenge. However, the possibility to deliver not only small drug molecules, but also macromolecular drugs and nanoparticles via mucosal surfaces represents a great opportunity. Rapid onset of drug action, avoidance of first-pass metabolism, and high immunocompetence of mucosa are some of the important features for mucosal drug and vaccine delivery. The use of mucoadhesive drug delivery systems, systems with fast-dissolving properties, and nanomaterials with mucus penetration properties are examples of successful strategies to achieve effective mucosal drug and vaccine delivery. Non-keratinised mucosa of the oral cavity, the nasal and vaginal mucosa represent favourable sites of drug administration. Polymer nanofibers have attracted much attention because of remarkable characteristics such as a large surface area to volume ratio and high porosity. Nanofibers have been extensively used for different biomedical applications including wound dressing, tissue engineering and drug delivery. Among their fabrication methods, the introduction of electrospinning technique was an important step towards achieving the goal of large scale industrial production of nanofiber-based drug delivery systems used in mucosal applications. This chapter provides an overview on all aspects of mucosal drug and vaccine delivery using nanofibers.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

20101 - Civil engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanomaterials: Toxicity, Human Health and Environment

ISBN

978-1-78984-616-4

Počet stran výsledku

28

Strana od-do

171-198

Počet stran knihy

231

Název nakladatele

IntechOpen

Místo vydání

London, UK

Kód UT WoS kapitoly

—