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Proteomic analysis of human tooth pulp proteomes - Comparison of caries-resistant and caries-susceptible persons

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10328014" target="_blank" >RIV/00064165:_____/16:10328014 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/16:10328014

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1016/j.jprot.2016.04.022" target="_blank" >http://dx.doi.org/10.1016/j.jprot.2016.04.022</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jprot.2016.04.022" target="_blank" >10.1016/j.jprot.2016.04.022</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Proteomic analysis of human tooth pulp proteomes - Comparison of caries-resistant and caries-susceptible persons

  • Popis výsledku v původním jazyce

    Most people in the world suffer from dental caries, > 90% of adults experience caries on enamel and root surfaces during their life. However, the overall roles of all factors in the development of dental caries still remain unclear and are worthy of recent investigation. In this study we used a proteomic 2D-DIGE approach in connection with MS/MS to investigate the different protein abundances in the tooth pulp of human third molars obtained from caries-resistant and caries-susceptible people. Statistical analysis of the two protein maps obtained on large gel (17 cm length) and mini gel (7 cm length) followed by nLC-MS/MS analysis enabled the identification of 16 significantly changed spots with unique protein identifications corresponding to 12 non-redundant proteins. Seven proteins exhibited higher and four proteins exhibited lower expression in the caries-resistant samples compared to the caries-susceptible samples. Additionally, one protein (alpha-1-antitrypsin) exhibited both expressions (up and down). Most of the differentially expressed proteins were associated with protein metabolism, energy production, cytoskeletal organization and transport. These differentially expressed proteins are likely involved in the natural resistance or susceptibility of humans to the development of dental caries and suggest that the resistance mechanism is multifactorial.

  • Název v anglickém jazyce

    Proteomic analysis of human tooth pulp proteomes - Comparison of caries-resistant and caries-susceptible persons

  • Popis výsledku anglicky

    Most people in the world suffer from dental caries, > 90% of adults experience caries on enamel and root surfaces during their life. However, the overall roles of all factors in the development of dental caries still remain unclear and are worthy of recent investigation. In this study we used a proteomic 2D-DIGE approach in connection with MS/MS to investigate the different protein abundances in the tooth pulp of human third molars obtained from caries-resistant and caries-susceptible people. Statistical analysis of the two protein maps obtained on large gel (17 cm length) and mini gel (7 cm length) followed by nLC-MS/MS analysis enabled the identification of 16 significantly changed spots with unique protein identifications corresponding to 12 non-redundant proteins. Seven proteins exhibited higher and four proteins exhibited lower expression in the caries-resistant samples compared to the caries-susceptible samples. Additionally, one protein (alpha-1-antitrypsin) exhibited both expressions (up and down). Most of the differentially expressed proteins were associated with protein metabolism, energy production, cytoskeletal organization and transport. These differentially expressed proteins are likely involved in the natural resistance or susceptibility of humans to the development of dental caries and suggest that the resistance mechanism is multifactorial.

Klasifikace

  • Druh

    J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

  • CEP obor

    FF - ORL, oftalmologie, stomatologie

  • OECD FORD obor

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NT14324" target="_blank" >NT14324: Srovnávací studie proteinového složení slin, pelikuly a zubů ve vztahu k zubnímu kazu</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2016

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Proteomics

  • ISSN

    1874-3919

  • e-ISSN

  • Svazek periodika

    145

  • Číslo periodika v rámci svazku

    August

  • Stát vydavatele periodika

    NL - Nizozemsko

  • Počet stran výsledku

    10

  • Strana od-do

    127-136

  • Kód UT WoS článku

    000383931000013

  • EID výsledku v databázi Scopus

    2-s2.0-84964864688