Differences of Saliva Composition in Relation to Tooth Decay and Gender

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00505673" target="_blank" >RIV/67985823:_____/18:00505673 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/18:10403631 RIV/00216208:11310/18:10403631 RIV/00064165:_____/18:10403631

Výsledek na webu

<a href="https://fb.cuni.cz/file/5885/fb2018a0024.pdf" target="_blank" >https://fb.cuni.cz/file/5885/fb2018a0024.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Differences of Saliva Composition in Relation to Tooth Decay and Gender

Popis výsledku v původním jazyce

Most people worldwide suffer from dental caries. Only a small part of the population is caries-resistant and the reason for this resistance in unknown. Only a few studies compared the saliva protein composition of persons with carious teeth and persons with no caries. Our study is the first to relate proteomic analysis of the caries aetiology with gender. In this study, we compared the differences in the abundances of proteins in the saliva between caries-resistant and caries-susceptible females and males by nano-liquid chromatography-tandem mass spectrometry (Label-Free Quantitative Proteomics). Our results demonstrate that the observed differences in the protein levels might have an influence on anti-caries resistance. A total of 19 potential markers of tooth caries were found, for example proteins S100A8 and annexin A1 with higher expression in the caries-susceptible group in comparison with the caries-free group and mucin-5B, lactoferrin, lysozyme C with higher expression in the caries-free group in comparison with the caries-susceptible group. The presented study is the first complex proteomic and gender project where the saliva protein content of caries-free and caries-susceptible persons were compared by label-free MS. The newly detected potential protein markers of dental caries can be a good basis for further research and for possible future therapeutic use.

Název v anglickém jazyce

Differences of Saliva Composition in Relation to Tooth Decay and Gender

Popis výsledku anglicky

Most people worldwide suffer from dental caries. Only a small part of the population is caries-resistant and the reason for this resistance in unknown. Only a few studies compared the saliva protein composition of persons with carious teeth and persons with no caries. Our study is the first to relate proteomic analysis of the caries aetiology with gender. In this study, we compared the differences in the abundances of proteins in the saliva between caries-resistant and caries-susceptible females and males by nano-liquid chromatography-tandem mass spectrometry (Label-Free Quantitative Proteomics). Our results demonstrate that the observed differences in the protein levels might have an influence on anti-caries resistance. A total of 19 potential markers of tooth caries were found, for example proteins S100A8 and annexin A1 with higher expression in the caries-susceptible group in comparison with the caries-free group and mucin-5B, lactoferrin, lysozyme C with higher expression in the caries-free group in comparison with the caries-susceptible group. The presented study is the first complex proteomic and gender project where the saliva protein content of caries-free and caries-susceptible persons were compared by label-free MS. The newly detected potential protein markers of dental caries can be a good basis for further research and for possible future therapeutic use.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/NV17-31564A" target="_blank" >NV17-31564A: Aplikace látek pro zefektivnění neinvazivní léčby fibrózního stavu u onemocnění pes equinovarus</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

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Svazek periodika

64

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

195-203

Kód UT WoS článku

000470083200006

EID výsledku v databázi Scopus

2-s2.0-85064208000