Urine sCD163: a window onto glomerular inflammation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F16%3A10337406" target="_blank" >RIV/00064165:_____/16:10337406 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10337406

Výsledek na webu

<a href="http://dx.doi.org/10.1093/ndt/gfw257" target="_blank" >http://dx.doi.org/10.1093/ndt/gfw257</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfw257" target="_blank" >10.1093/ndt/gfw257</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Urine sCD163: a window onto glomerular inflammation

Popis výsledku v původním jazyce

Several antibodies to an unknown monocyte/macrophage-specific antigen were described in the 1980s and 1990s, leading to the CD163 designation at the 6th Leukocyte Typing Workshop in 1996. The principal function of this membrane-bound protein as a monocyte/macrophage-specific scavenger receptor for haemoglobin-haptoglobin complexes was described in 2001, and soon after it was realized that relatively high concentrations of a soluble form of the receptor are present in the circulation (soluble CD163, sCD163). The soluble form probably functions as part of the innate immune defence by reversibly binding bacteria and free haemoglobin in the circulation for further processing by the immune system. However, due to the high and specific expression on macrophages, sCD163 has gained much attention as a potential biomarker reflecting macrophage activation in inflammatory conditions.

Název v anglickém jazyce

Urine sCD163: a window onto glomerular inflammation

Popis výsledku anglicky

Several antibodies to an unknown monocyte/macrophage-specific antigen were described in the 1980s and 1990s, leading to the CD163 designation at the 6th Leukocyte Typing Workshop in 1996. The principal function of this membrane-bound protein as a monocyte/macrophage-specific scavenger receptor for haemoglobin-haptoglobin complexes was described in 2001, and soon after it was realized that relatively high concentrations of a soluble form of the receptor are present in the circulation (soluble CD163, sCD163). The soluble form probably functions as part of the innate immune defence by reversibly binding bacteria and free haemoglobin in the circulation for further processing by the immune system. However, due to the high and specific expression on macrophages, sCD163 has gained much attention as a potential biomarker reflecting macrophage activation in inflammatory conditions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nephrology, Dialysis, Transplantation

ISSN

0931-0509

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

1970-1972

Kód UT WoS článku

000393059700002

EID výsledku v databázi Scopus

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