Factors Responsible for Cerebral Hypoxia in Hemodialysis Population
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10399145" target="_blank" >RIV/00064165:_____/19:10399145 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/19:10399145
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U7DSmRuRp~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=U7DSmRuRp~</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934064" target="_blank" >10.33549/physiolres.934064</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Factors Responsible for Cerebral Hypoxia in Hemodialysis Population
Popis výsledku v původním jazyce
Brain tissue oxygenation (rSO(2)) measured by near-infrared spectroscopy (NIRS) is lower in hemodialysis patients than in the healthy population and is associated with cognitive dysfunction. The involved mechanisms are not known. We conducted this study to identify the factors that influence the rSO(2) values in end-stage renal disease (ESRD) patients and to describe rSO(2) changes during hemodialysis. We included a cohort of ESRD patients hemodialyzed in our institution. We recorded rSO(2) using INVOS 5100C oximetry system (Medtronic, Essex, U.K.) and analyzed changes in basic laboratory values and hemodynamic fluctuations. Baseline rSO(2) was lower in patients with heart failure (45.2 +/- 8.3 % vs. 54.1 +/- 7.8 %, p=0.006) and was significantly linked to higher red cell distribution width (RDW) (r=-0.53, p<0.001) and higher BNP level (r=-0.45, p=0.01). The rSO(2) value decreased in first 15 min of hemodialysis, this decrease correlated with drop in white blood count during the same period (r=0.43, p=0.02 in 10 min, r=0.43, p=0.02 in 20 min). Lower rSO(2) values in patients with heart failure and higher RDW suggest that hemodynamic instability combined with vascular changes probably leads to worse cerebral oxygenation in these patients. Decrease of rSO(2) in 15th minute of hemodialysis accompanied with a significant drop in leukocyte count could be explained by complement activation.
Název v anglickém jazyce
Factors Responsible for Cerebral Hypoxia in Hemodialysis Population
Popis výsledku anglicky
Brain tissue oxygenation (rSO(2)) measured by near-infrared spectroscopy (NIRS) is lower in hemodialysis patients than in the healthy population and is associated with cognitive dysfunction. The involved mechanisms are not known. We conducted this study to identify the factors that influence the rSO(2) values in end-stage renal disease (ESRD) patients and to describe rSO(2) changes during hemodialysis. We included a cohort of ESRD patients hemodialyzed in our institution. We recorded rSO(2) using INVOS 5100C oximetry system (Medtronic, Essex, U.K.) and analyzed changes in basic laboratory values and hemodynamic fluctuations. Baseline rSO(2) was lower in patients with heart failure (45.2 +/- 8.3 % vs. 54.1 +/- 7.8 %, p=0.006) and was significantly linked to higher red cell distribution width (RDW) (r=-0.53, p<0.001) and higher BNP level (r=-0.45, p=0.01). The rSO(2) value decreased in first 15 min of hemodialysis, this decrease correlated with drop in white blood count during the same period (r=0.43, p=0.02 in 10 min, r=0.43, p=0.02 in 20 min). Lower rSO(2) values in patients with heart failure and higher RDW suggest that hemodynamic instability combined with vascular changes probably leads to worse cerebral oxygenation in these patients. Decrease of rSO(2) in 15th minute of hemodialysis accompanied with a significant drop in leukocyte count could be explained by complement activation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30217 - Urology and nephrology
Návaznosti výsledku
Projekt
<a href="/cs/project/NV17-31796A" target="_blank" >NV17-31796A: Tkáňová hypoxie u pacientů s chronickým onemocněním ledvin – metabolické a hemodynamické souvislosti</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
—
Svazek periodika
68
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
651-658
Kód UT WoS článku
000483374200013
EID výsledku v databázi Scopus
2-s2.0-85071711603