Brain perfusion evaluated by regional tissue oxygenation as a possible quality indicator of ongoing cardiopulmonary resuscitation. An experimental porcine cardiac arrest study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376842" target="_blank" >RIV/00216208:11110/18:10376842 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/18:00327583 RIV/00064165:_____/18:10376842

Výsledek na webu

<a href="https://doi.org/10.1177/0267659118766282" target="_blank" >https://doi.org/10.1177/0267659118766282</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0267659118766282" target="_blank" >10.1177/0267659118766282</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain perfusion evaluated by regional tissue oxygenation as a possible quality indicator of ongoing cardiopulmonary resuscitation. An experimental porcine cardiac arrest study

Popis výsledku v původním jazyce

Introduction: Relationship between regional tissue oxygenation (rSO(2)) and microcirculatory changes during cardiac arrest (CA) are still unclear. Therefore, we designed an experimental study to correlate rSO(2), microcirculation and systemic hemodynamic parameters in a porcine model of CA. Methods: Ventricular fibrillation was induced in 24 female pigs (503kg) and left for three minutes untreated followed by five minutes of mechanical CPR. Regional and peripheral saturations were assessed by near-infrared spectroscopy, sublingual microcirculation by Sidestream Dark Field technology and continuous hemodynamic parameters, including systemic blood pressure (MAP) and carotid blood flow (CF), during baseline, CA and CPR periods. The Wilcoxon Signed-Rank test, the Friedman test and the partial correlation method were used to compare these parameters. Results: Brain and peripheral rSO(2) showed a gradual decrease during CA and only an increase of brain rSO(2) during mechanical CPR (34.5 to 42.5; p=0.0001), reflected by a rapid decrease of microcirculatory and hemodynamic parameters during CA and a slight increase during CPR. Peripheral rSO(2) was not changed significantly during CPR (38 to 38.5; p=0.09). We only found a moderate correlation of cerebral/peripheral rSO(2) to microcirculatory parameters (PVD: r=0.53/0.46; PPV: r=0.6/0.5 and MFI: r=0.64/0.52) and hemodynamic parameters (MAP: r=0.64/0.71 and CF: 0.71/0.67). Conclusions: Our experimental study confirmed that monitoring brain and peripheral rSO(2) is an easy-to-use method, well reflecting the hemodynamics during CA. However, only brain rSO(2) reflects the CPR efforts and might be used as a potential quality indicator for CPR.

Název v anglickém jazyce

Brain perfusion evaluated by regional tissue oxygenation as a possible quality indicator of ongoing cardiopulmonary resuscitation. An experimental porcine cardiac arrest study

Popis výsledku anglicky

Introduction: Relationship between regional tissue oxygenation (rSO(2)) and microcirculatory changes during cardiac arrest (CA) are still unclear. Therefore, we designed an experimental study to correlate rSO(2), microcirculation and systemic hemodynamic parameters in a porcine model of CA. Methods: Ventricular fibrillation was induced in 24 female pigs (503kg) and left for three minutes untreated followed by five minutes of mechanical CPR. Regional and peripheral saturations were assessed by near-infrared spectroscopy, sublingual microcirculation by Sidestream Dark Field technology and continuous hemodynamic parameters, including systemic blood pressure (MAP) and carotid blood flow (CF), during baseline, CA and CPR periods. The Wilcoxon Signed-Rank test, the Friedman test and the partial correlation method were used to compare these parameters. Results: Brain and peripheral rSO(2) showed a gradual decrease during CA and only an increase of brain rSO(2) during mechanical CPR (34.5 to 42.5; p=0.0001), reflected by a rapid decrease of microcirculatory and hemodynamic parameters during CA and a slight increase during CPR. Peripheral rSO(2) was not changed significantly during CPR (38 to 38.5; p=0.09). We only found a moderate correlation of cerebral/peripheral rSO(2) to microcirculatory parameters (PVD: r=0.53/0.46; PPV: r=0.6/0.5 and MFI: r=0.64/0.52) and hemodynamic parameters (MAP: r=0.64/0.71 and CF: 0.71/0.67). Conclusions: Our experimental study confirmed that monitoring brain and peripheral rSO(2) is an easy-to-use method, well reflecting the hemodynamics during CA. However, only brain rSO(2) reflects the CPR efforts and might be used as a potential quality indicator for CPR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Perfusion

ISSN

0267-6591

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

Supplement 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

65-70

Kód UT WoS článku

000432998400009

EID výsledku v databázi Scopus

2-s2.0-85047437605