Tissue ischemia worsens during hemodialysis in end-stage renal disease patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10361956" target="_blank" >RIV/00216208:11110/17:10361956 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10361956

Výsledek na webu

<a href="http://dx.doi.org/10.5301/jva.5000630" target="_blank" >http://dx.doi.org/10.5301/jva.5000630</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5301/jva.5000630" target="_blank" >10.5301/jva.5000630</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tissue ischemia worsens during hemodialysis in end-stage renal disease patients

Popis výsledku v původním jazyce

Background: Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis. Methods: Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected. Results: Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 +/- 10.9 vs. 68 +/- 7%, p&lt; 0.0001 and 55 +/- 16 vs. 66 +/- 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 +/- 8%, p&lt; 0.0001 and hand to 45 +/- 14%, p&lt; 0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin. Conclusions: Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.

Název v anglickém jazyce

Tissue ischemia worsens during hemodialysis in end-stage renal disease patients

Popis výsledku anglicky

Background: Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis. Methods: Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected. Results: Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 +/- 10.9 vs. 68 +/- 7%, p&lt; 0.0001 and 55 +/- 16 vs. 66 +/- 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 +/- 8%, p&lt; 0.0001 and hand to 45 +/- 14%, p&lt; 0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin. Conclusions: Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Vascular Access

ISSN

1129-7298

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

5

Strana od-do

47-51

Kód UT WoS článku

000395837400015

EID výsledku v databázi Scopus

2-s2.0-85010332836