Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10505137" target="_blank" >RIV/00064165:_____/25:10505137 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10505137

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j2nq8Z8Tk0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j2nq8Z8Tk0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.isci.2025.113725" target="_blank" >10.1016/j.isci.2025.113725</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors

Popis výsledku v původním jazyce

Assessment of Different Neoplasias in the Adnexa (ADNEX) is the best-performing model to estimate the risk of malignancy in ovarian tumors. We assessed the incremental value of serum proteins over ADNEX predictors in an exploratory multicenter study. In a cohort of 932 patients with an adnexal mass scheduled for surgery, 33 serum proteins were preoperatively quantified using multiplex high-throughput and electrochemiluminescence immunoassays. Using multivariable logistic regression, ADNEX predictors alone had an area under the receiver operating characteristic curve (AUC) of 0.91 (95% confidence interval, 0.89-0.93) to discriminate benign from malignant tumors. This AUC increased most after adding HE4 (+0.03) or CA125 (+0.02). CA72.4 increased AUCs to discriminate secondary metastatic tumors from benign (+0.03), borderline (+0.03), and stage I tumors (+0.03). CA15.3 increased AUCs to discriminate borderline tumors from stage I (+0.01) and stage II-IV tumors (+0.03). While CA125 and HE4 had the highest added value over ADNEX predictors, CA72.4 and CA15.3 may improve discrimination between malignant subtypes.

Název v anglickém jazyce

Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors

Popis výsledku anglicky

Assessment of Different Neoplasias in the Adnexa (ADNEX) is the best-performing model to estimate the risk of malignancy in ovarian tumors. We assessed the incremental value of serum proteins over ADNEX predictors in an exploratory multicenter study. In a cohort of 932 patients with an adnexal mass scheduled for surgery, 33 serum proteins were preoperatively quantified using multiplex high-throughput and electrochemiluminescence immunoassays. Using multivariable logistic regression, ADNEX predictors alone had an area under the receiver operating characteristic curve (AUC) of 0.91 (95% confidence interval, 0.89-0.93) to discriminate benign from malignant tumors. This AUC increased most after adding HE4 (+0.03) or CA125 (+0.02). CA72.4 increased AUCs to discriminate secondary metastatic tumors from benign (+0.03), borderline (+0.03), and stage I tumors (+0.03). CA15.3 increased AUCs to discriminate borderline tumors from stage I (+0.01) and stage II-IV tumors (+0.03). While CA125 and HE4 had the highest added value over ADNEX predictors, CA72.4 and CA15.3 may improve discrimination between malignant subtypes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

iScience

ISSN

2589-0042

e-ISSN

2589-0042

Svazek periodika

28

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

17

Strana od-do

113725

Kód UT WoS článku

001607289300001

EID výsledku v databázi Scopus

2-s2.0-105020267834