Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F10%3A%230000049" target="_blank" >RIV/00064173:_____/10:#0000049 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

Popis výsledku v původním jazyce

It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis).

Název v anglickém jazyce

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.

Popis výsledku anglicky

It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NS10369" target="_blank" >NS10369: Využití neurocytoskeletálních proteinů a protilátek proti nim v diagnostice Alzheimerovy nemoci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biosystems

ISSN

1742-206X

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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