Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F10%3A00001075" target="_blank" >RIV/00023752:_____/10:00001075 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/10:00002448

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

Popis výsledku v původním jazyce

It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin Tbased fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescenceof samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence afluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) signifi

Název v anglickém jazyce

Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

Popis výsledku anglicky

It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin Tbased fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescenceof samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence afluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) signifi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biosystems

ISSN

1742-206X

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000282765000013

EID výsledku v databázi Scopus

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